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Chemical Compound Review:

CHEBI:72686 (4R,5S,6R,7R)-5,6,7,8- tetrahydroxy-2-oxo-4...

Synonyms: AC1L3187, 143651-48-3, Kdo-4-phosphate, 3-Deoxy-2-octulosonate-4-phosphate, 3-Deoxy-D-manno-2-octulosonate-4-phosphate

Kondo, S. et al., Rozalski, A. et al.

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Disease relevance of Kdo-4-phosphate

The undetectability of Kdo in LPS after conventional hydrolysis and the occurrence of phosphorylated Kdo in strong-acid hydrolysates and of Kdo 4-phosphate in the inner-core region are taxonomic characteristics of the family Vibrionaceae [1].

High impact information on Kdo-4-phosphate

Three antibodies were specific for 3-deoxy-D-manno-octulopyranosonic acid- (Kdo) 5-phosphate, one for Kdo-4-phosphate, and one required, in addition to a Kdo-phosphate, parts of the phosphorylated glucosamine backbone of lipid A [2].

References

Taxonomic implication of the apparent undetectability of 3-deoxy-D-manno-2-octulosonate (Kdo) in lipopolysaccharides of the representatives of the family Vibrionaceae and the occurrence of Kdo 4-phosphate in their inner-core regions. Kondo, S., Haishima, Y., Hisatsune, K. Carbohydr. Res. (1992) [Pubmed]
Characterization of monoclonal antibodies recognizing three distinct, phosphorylated carbohydrate epitopes in the lipopolysaccharide of the deep rough mutant I-69 Rd-/b+ of Haemophilus influenzae. Rozalski, A., Brade, L., Kosma, P., Moxon, R., Kusumoto, S., Brade, H. Mol. Microbiol. (1997) [Pubmed]

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