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Chemical Compound Review

AC1L31X3     2-[[(1S)-1-[[(1S)-3-methyl- 1...

Synonyms: L-696,418, L 696418, L696,418, 154096-58-9, Cepe-gly-leu-PA
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High impact information on Cepe-gly-leu-PA

  • To characterize the effects of intraarticular injection of recombinant human stromelysin (SLN) on the matrix composition and physical properties of cartilage from lapine stifle joints and the modulation of these effects by the systemic administration of an N-carboxyalkyl synthetic matrix metalloproteinase inhibitor, L-696,418 [1].
  • Lapine stifle joints that received injection of SLN without systemic administration of L-696,418 showed a 13-fold increase in loss of PG into synovial fluid [1].

Analytical, diagnostic and therapeutic context of Cepe-gly-leu-PA


  1. In vivo effects of stromelysin on the composition and physical properties of rabbit articular cartilage in the presence and absence of a synthetic inhibitor. Bonassar, L.J., Jeffries, K.A., Frank, E.H., Moore, V.L., Lark, M.W., Bayne, E.K., McDonnell, J., Olszewski, J., Hagmann, W., Chapman, K. Arthritis Rheum. (1995) [Pubmed]
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