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Chemical Compound Review

CHEMBL2107258     4-[4-[2-[(1S)-isochroman-1...

Synonyms: PNU-101387G, LS-182297, PNU 101387G, AC1L3253, U-101387G, ...
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Psychiatry related information on U-101387

  • The current study performed a preliminary examination of the role of D4 receptor mechanisms by determining whether the selective D4 receptor antagonist, PNU-101387G, could prevent stress-induced working memory deficits in monkeys [1].
 

High impact information on U-101387

  • Similarly, the D4R antagonist PNU-101387G prevented hyperactivity in wild-type 6-OHDA-lesioned mice [2].

References

  1. The selective dopamine D4 receptor antagonist, PNU-101387G, prevents stress-induced cognitive deficits in monkeys. Arnsten, A.F., Murphy, B., Merchant, K. Neuropsychopharmacology (2000) [Pubmed]
  2. The dopamine D4 receptor is essential for hyperactivity and impaired behavioral inhibition in a mouse model of attention deficit/hyperactivity disorder. Avale, M.E., Falzone, T.L., Gelman, D.M., Low, M.J., Grandy, D.K., Rubinstein, M. Mol. Psychiatry (2004) [Pubmed]
 
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