Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AG-H-38964 3-(2-imino-3-phosphono- imidazolidin-1...

Synonyms: SureCN7819308, CTK3E8348, AC1L35BH, 84744-77-4, Homocyclocreatine-P, ...

Roberts, J.J. et al., Turner, D.M. et al.

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Disease relevance of Phosphohomocyclocreatine

During ischemia homocyclocreatine-P was utilized by muscle much more slowly for the regeneration of ATP than was creatine-P or cyclocreatine-P [1].

High impact information on Phosphohomocyclocreatine

During ischemia these hearts exhibited prolonged glycolysis, but they did not utilize the very stable homocyclocreatine-P (200,000-fold less reactive than creatine-P) and thus formed less Pi; most significantly, there was no delay in depletion of ATP levels relative to controls [2].
Chicks fed 5% homocyclocreatine for 16 days synthesized and accumulated homocyclocreatine-P in breast muscle (32 mumol/g wet wt), leg muscle (24 mumol/g), heart (7 mumol/g), intestine (8.5 mumol/g), and brain (2.4 mumol/g) [1].

References

Synthesis and accumulation of an extremely stable high-energy phosphate compound by muscle, heart, and brain of animals fed the creatine analog, 1-carboxyethyl-2-iminoimidazolidine (homocyclocreatine). Roberts, J.J., Walker, J.B. Arch. Biochem. Biophys. (1983) [Pubmed]
Relative abilities of phosphagens with different thermodynamic or kinetic properties to help sustain ATP and total adenylate pools in heart during ischemia. Turner, D.M., Walker, J.B. Arch. Biochem. Biophys. (1985) [Pubmed]

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