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Disease relevance of Glycolysis


Psychiatry related information on Glycolysis

  • The marked inhibition of brain and muscles phosphofructokinase (the rate-limiting enzyme in glycolysis) induced by Li+, may play an important role in the mechanism of the therapeutic action of this agent in the manic state [6].
  • The capacity for glycolysis in muscle biopsies obtained from long-term heavy alcohol drinking patients has been compared with tissue from control subjects by assay in vitro of the total activities of glycogen phosphorylase, phosphofructokinase and fructose 1,6-bisphosphatase, key regulatory enzymes in the anaerobic glycolytic pathway [7].
  • Time-response studies with Ca(2+)-ionophore A23187 have revealed dual effects on the distribution of phosphofructokinase (PFK) (EC, the rate-limiting enzyme of glycolysis, between the cytoskeletal and cytosolic (soluble) fractions of the cell [8].
  • It is suggested that acetylcholine liberated from sympathetic fibres causes the activation of glycolysis in muscles, which in its turn induces vasodilation in resting skeletal muscles and increase of muscle performance during emotional stress [9].

High impact information on Glycolysis


Chemical compound and disease context of Glycolysis


Biological context of Glycolysis


Anatomical context of Glycolysis


Associations of Glycolysis with chemical compounds


Gene context of Glycolysis

  • Only one gene coding for glyceraldehyde 3-phosphate dehydrogenase (GAPDH, EC, a key enzyme in the control of glycolysis, is known to be functional in man, mouse, rat and chicken [34].
  • Furthermore, CD28 controls a primary response pathway, inducing a level of glucose uptake and glycolysis in excess of that needed to maintain cellular ATP/ADP levels or macromolecular synthesis [25].
  • Enhanced glycerol production caused by overexpression of GPD1 encoding glycerol-3-phosphate dehydrogenase also suppressed the growth defect of ggs1/tps1 delta mutants, suggesting a novel role for glycerol production in the control of glycolysis [35].
  • Phosphofructokinase (PFK) plays a major role in glycolysis [36].
  • 6-Phosphofructokinase (PFK) plays a central role in the regulation of glycolysis in both normal and neoplastic cells [37].

Analytical, diagnostic and therapeutic context of Glycolysis


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  19. The neurotrophic factor neuroleukin is 90% homologous with phosphohexose isomerase. Chaput, M., Claes, V., Portetelle, D., Cludts, I., Cravador, A., Burny, A., Gras, H., Tartar, A. Nature (1988) [Pubmed]
  20. Glycolysis preferentially inhibits ATP-sensitive K+ channels in isolated guinea pig cardiac myocytes. Weiss, J.N., Lamp, S.T. Science (1987) [Pubmed]
  21. Alkylating DNA damage stimulates a regulated form of necrotic cell death. Zong, W.X., Ditsworth, D., Bauer, D.E., Wang, Z.Q., Thompson, C.B. Genes Dev. (2004) [Pubmed]
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  30. Human testis-specific PGK gene lacks introns and possesses characteristics of a processed gene. McCarrey, J.R., Thomas, K. Nature (1987) [Pubmed]
  31. Synergistic effects of substrate-induced conformational changes in phosphoglycerate kinase activation. Bernstein, B.E., Michels, P.A., Hol, W.G. Nature (1997) [Pubmed]
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  35. Fps1, a yeast member of the MIP family of channel proteins, is a facilitator for glycerol uptake and efflux and is inactive under osmotic stress. Luyten, K., Albertyn, J., Skibbe, W.F., Prior, B.A., Ramos, J., Thevelein, J.M., Hohmann, S. EMBO J. (1995) [Pubmed]
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  39. Glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme, is required for sperm motility and male fertility. Miki, K., Qu, W., Goulding, E.H., Willis, W.D., Bunch, D.O., Strader, L.F., Perreault, S.D., Eddy, E.M., O'Brien, D.A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
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