Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1Q5RYT 5-hydroxy-2-propyl-pentanoic acid

Synonyms: AR-1L0027, AKOS006279686, FT-0670215, AC1L362K, C16650, ...

Rettie, A.E. et al., Schäfer, H. et al.

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High impact information on 5-Hydroxyvalproic acid

Analyses of metabolites by GC/MS indicated the formation of 3-hydroxy-, 4-hydroxy-, and 5-hydroxyvalproic acid, with hydroxylation occurring preferentially at the 4- position [1].
Metabolite pattern of valproic acid. Part I: gaschromatographic determination of the valproic acid metabolite artifacts, heptanone-3, 4- and 5-hydroxyvalproic acid lactone [2].

References

Valproate hydroxylation by human fetal tissues and embryotoxicity of metabolites. Rettie, A.E., Rettenmeier, A.W., Beyer, B.K., Baillie, T.A., Juchau, M.R. Clin. Pharmacol. Ther. (1986) [Pubmed]
Metabolite pattern of valproic acid. Part I: gaschromatographic determination of the valproic acid metabolite artifacts, heptanone-3, 4- and 5-hydroxyvalproic acid lactone. Schäfer, H., Lührs, R. Arzneimittel-Forschung. (1978) [Pubmed]

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