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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Hydroxylation


Psychiatry related information on Hydroxylation


High impact information on Hydroxylation


Chemical compound and disease context of Hydroxylation


Biological context of Hydroxylation


Anatomical context of Hydroxylation


Associations of Hydroxylation with chemical compounds

  • We report that the activities of both cytochromes depend critically on the identities of the amino acids at positions 117, 209 and 365 and, moreover, that a single mutation in which Phe 209 is substituted by Leu is sufficient to convert the specificity of P450coh from coumarin to steroid hydroxylation [30].
  • Nonenzymatic hydroxylations of proline and lysine by reduced oxygen derivatives [31].
  • The rise in luminal PTH concentration should also stimulate the hydroxylation of 25(OH) vitamin D3 to the active hormone [32].
  • Titanium silicalite is an effective molecular-sieve catalyst for the selective oxidation of alkanes, the hydroxylation of phenol and the epoxidation of alkenes in the presence of H2O2 (refs 1-3) [33].
  • We found that these small peptides contained the trans-3 and cis-4 isomers of hydroxyproline as well as trans-4 ones and that their production was not completely inhibited by alpha, alpha-dipyridyl, and iron chelator and effective inhibitor of enzyme-mediated hydroxylations [31].

Gene context of Hydroxylation


Analytical, diagnostic and therapeutic context of Hydroxylation


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