MeSH Review:
Hydroxylation
- 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol: conversion impaired by systemic metabolic acidosis. Lee, S.W., Russell, J., Avioli, L.V. Science (1977)
- Phenylketonuria and other phenylalanine hydroxylation mutants in man. Scriver, C.R., Clow, C.L. Annu. Rev. Genet. (1980)
- Retroviral-mediated gene transfer of human phenylalanine hydroxylase into NIH 3T3 and hepatoma cells. Ledley, F.D., Grenett, H.E., McGinnis-Shelnutt, M., Woo, S.L. Proc. Natl. Acad. Sci. U.S.A. (1986)
- Use of aromatic hydroxylation of phenylalanine to measure production of hydroxyl radicals after myocardial ischemia in vivo. Direct evidence for a pathogenetic role of the hydroxyl radical in myocardial stunning. Sun, J.Z., Kaur, H., Halliwell, B., Li, X.Y., Bolli, R. Circ. Res. (1993)
- Free radical damage to protein and DNA: mechanisms involved and relevant observations on brain undergoing oxidative stress. Floyd, R.A., Carney, J.M. Ann. Neurol. (1992)
- Brain tyrosine hydroxylation: alteration of oxygen affinity in vivo by immobilization or electroshock in the rat. Davis, J.N. J. Neurochem. (1976)
- Ontogenetic development of locomotor activity and rate of tyrosine hydroxylation. Melberg, P.E., Ahlenius, S., Engel, J., Lundborg, P. Psychopharmacology (Berl.) (1976)
- Superoxide dismutase activity in Alzheimer's disease: possible mechanism for paired helical filament formation. Zemlan, F.P., Thienhaus, O.J., Bosmann, H.B. Brain Res. (1989)
- Intracranial self-stimulation increases differentially in vivo hydroxylation of tyrosine but similarly in vivo hydroxylation of tryptophan in rat medial prefrontal cortex, nucleus accumbens and striatum. Nakahara, D., Nakamura, M., Furukawa, H., Furuno, N. Brain Res. (2000)
- Proline hydroxylation and gene expression. Kaelin, W.G. Annu. Rev. Biochem. (2005)
- Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation. Jeong, J.W., Bae, M.K., Ahn, M.Y., Kim, S.H., Sohn, T.K., Bae, M.H., Yoo, M.A., Song, E.J., Lee, K.J., Kim, K.W. Cell (2002)
- Light and brassinosteroid signals are integrated via a dark-induced small G protein in etiolated seedling growth. Kang, J.G., Yun, J., Kim, D.H., Chung, K.S., Fujioka, S., Kim, J.I., Dae, H.W., Yoshida, S., Takatsuto, S., Song, P.S., Park, C.M. Cell (2001)
- Hyperphenylalaninemia due to a deficiency of biopterin. A variant form of phenylketonuria. Kaufman, S., Berlow, S., Summer, G.K., Milstien, S., Schulman, J.D., Orloff, S., Spielberg, S., Pueschel, S. N. Engl. J. Med. (1978)
- Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. Hon, W.C., Wilson, M.I., Harlos, K., Claridge, T.D., Schofield, C.J., Pugh, C.W., Maxwell, P.H., Ratcliffe, P.J., Stuart, D.I., Jones, E.Y. Nature (2002)
- Phenylketonuria. The in vivo hydroxylation rate of phenylalanine into tyrosine is decreased. van Spronsen, F.J., Reijngoud, D.J., Smit, G.P., Nagel, G.T., Stellaard, F., Berger, R., Heymans, H.S. J. Clin. Invest. (1998)
- Significant phenylalanine hydroxylation in vivo in patients with classical phenylketonuria. Thompson, G.N., Halliday, D. J. Clin. Invest. (1990)
- Cytochrome P450 1B1 (CYP1B1) pharmacogenetics: association of polymorphisms with functional differences in estrogen hydroxylation activity. Hanna, I.H., Dawling, S., Roodi, N., Guengerich, F.P., Parl, F.F. Cancer Res. (2000)
- In micronodular cirrhosis, hepatocytes retain a normal C-25 hydroxylation capacity toward vitamin D3: a study using the rat carbon tetrachloride-induced cirrhotic model. Dubé, C., Vallières, S., Ethier, C., Benbrahim, N., Tremblay, C., Gascon-Barré, M. Hepatology (1991)
- An animal model of early-treated PKU. Diamond, A., Ciaramitaro, V., Donner, E., Djali, S., Robinson, M.B. J. Neurosci. (1994)
- Aureusidin synthase: a polyphenol oxidase homolog responsible for flower coloration. Nakayama, T., Yonekura-Sakakibara, K., Sato, T., Kikuchi, S., Fukui, Y., Fukuchi-Mizutani, M., Ueda, T., Nakao, M., Tanaka, Y., Kusumi, T., Nishino, T. Science (2000)
- FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Lando, D., Peet, D.J., Gorman, J.J., Whelan, D.A., Whitelaw, M.L., Bruick, R.K. Genes Dev. (2002)
- Mutagenicity of five cyclic N-nitrosamines: assay with Salmonella typhimurium. Stoltz, D.R., Sen, N.P. J. Natl. Cancer Inst. (1977)
- Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2. Yamanaka, K., Ishikawa, H., Megumi, Y., Tokunaga, F., Kanie, M., Rouault, T.A., Morishima, I., Minato, N., Ishimori, K., Iwai, K. Nat. Cell Biol. (2003)
- Doxorubicin-induced inhibition of prolyl hydroxylation during collagen biosynthesis in human skin fibroblast cultures. Relevance to imparied wound healing. Sasaki, T., Holeyfield, K.C., Uitto, J. J. Clin. Invest. (1987)
- Cyclical oxidation-reduction of the C3 position on bile acids catalyzed by rat hepatic 3 alpha-hydroxysteroid dehydrogenase. I. Studies with the purified enzyme, isolated rat hepatocytes, and inhibition by indomethacin. Takikawa, H., Stolz, A., Kaplowitz, N. J. Clin. Invest. (1987)
- Mitochondrial oxidative stress after carbon monoxide hypoxia in the rat brain. Zhang, J., Piantadosi, C.A. J. Clin. Invest. (1992)
- Isolation and characterization of monoclonal antibodies directed against plant plasma membrane and cell wall epitopes: identification of a monoclonal antibody that recognizes extensin and analysis of the process of epitope biosynthesis in plant tissues and cell cultures. Meyer, D.J., Afonso, C.L., Galbraith, D.W. J. Cell Biol. (1988)
- Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug. Beaune, P., Dansette, P.M., Mansuy, D., Kiffel, L., Finck, M., Amar, C., Leroux, J.P., Homberg, J.C. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Enhancement of hydroxylation and deglycosylation of 2'-deoxyguanosine by carcinogenic nickel compounds. Kasprzak, K.S., Hernandez, L. Cancer Res. (1989)
- Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue. Lindberg, R.L., Negishi, M. Nature (1989)
- Nonenzymatic hydroxylations of proline and lysine by reduced oxygen derivatives. Trelstad, R.L., Lawley, K.R., Holmes, L.B. Nature (1981)
- ClC-5 Cl- -channel disruption impairs endocytosis in a mouse model for Dent's disease. Piwon, N., Günther, W., Schwake, M., Bösl, M.R., Jentsch, T.J. Nature (2000)
- Titanium-containing mesoporous molecular sieves for catalytic oxidation of aromatic compounds. Tanev, P.T., Chibwe, M., Pinnavaia, T.J. Nature (1994)
- The DWF4 gene of Arabidopsis encodes a cytochrome P450 that mediates multiple 22alpha-hydroxylation steps in brassinosteroid biosynthesis. Choe, S., Dilkes, B.P., Fujioka, S., Takatsuto, S., Sakurai, A., Feldmann, K.A. Plant Cell (1998)
- An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Xie, W., Radominska-Pandya, A., Shi, Y., Simon, C.M., Nelson, M.C., Ong, E.S., Waxman, D.J., Evans, R.M. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor. Goodwin, B., Gauthier, K.C., Umetani, M., Watson, M.A., Lochansky, M.I., Collins, J.L., Leitersdorf, E., Mangelsdorf, D.J., Kliewer, S.A., Repa, J.J. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes. Chang, T.K., Weber, G.F., Crespi, C.L., Waxman, D.J. Cancer Res. (1993)
- Pretranslational down-regulation of cytochromes P450 2C11 and 3A2 in male rat liver by tumor necrosis factor alpha. Nadin, L., Butler, A.M., Farrell, G.C., Murray, M. Gastroenterology (1995)
- Abnormal phenylalanine hydroxylation and tyrosine oxidation in a patient with acute fulminant liver disease with correction by liver transplantation. Hehir, D.J., Jenkins, R.L., Bistrian, B.R., Wagner, D., Moldawer, L.L., Young, V.R., Blackburn, G.L. Gastroenterology (1985)
- Conformational implications of enzymatic proline hydroxylation in collagen. Chopra, R.K., Ananthanarayanan, V.S. Proc. Natl. Acad. Sci. U.S.A. (1982)
- Engineering a mineralocorticoid- to a glucocorticoid-synthesizing cytochrome P450. Böttner, B., Schrauber, H., Bernhardt, R. J. Biol. Chem. (1996)