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Chemical Compound Review:

CHEMBL83088 phenanthren-9-amine

Synonyms: CCRIS 7006, AG-H-91092, ACMC-20alvr, CHEBI:50475, KB-46963, ...

Yoon, M.Y. et al., Cupp-Vickery, J. et al.

Cupp-Vickery, Anderson, Hatziris,

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High impact information on phenanthren-9-amine

The P450eryF/9-aminophenanthrene model was refined to an r = 19.7% with the proximal 9-aminophenanthrene coordinated with the heme iron through the 9-amino group and the second ligand positioned approximately 6 A distal in the active site [1].
Furthermore, the results provide proof of principle for NMR as a method for studying CYP allosterism, and demonstrate that the model ligand 9-aminophenanthrene binds in two discrete events to individual subsites within the active site of CYP(eryF) [2].

References

Crystal structures of ligand complexes of P450eryF exhibiting homotropic cooperativity. Cupp-Vickery, J., Anderson, R., Hatziris, Z. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
"Allosterism" in the elementary steps of the cytochrome P450 reaction cycle. Yoon, M.Y., Campbell, A.P., Atkins, W.M. Drug Metab. Rev. (2004) [Pubmed]

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