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Chemical Compound Review:

Thiochroman thiochroman

Synonyms: benzothiane, Thiochromane, SureCN130168, AG-E-50660, AC1L3AJF, ...

Spruce, L.W. et al., Kanbe, Y. et al.

Kanbe, Kim, Nishimoto, Ohtake, Kato, Tsunenari, Taniguchi, Ohizumi, Kaiho, Morikawa, Jo, Lim, Kim,

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High impact information on thiochroman

With a benzoic acid group as part of the structure attached to the thiochroman unit, the ODC activity was enhanced as shown in 10 and 11 [1].
Discovery of thiochroman and chroman derivatives as pure antiestrogens and their structure-activity relationship [2].

Gene context of thiochroman

With a thiochroman unit, the most active acids in decreasing order of activity in the ODC assay were 7 greater than 9 greater than 8 [1].

References

Novel heteroarotinoids: synthesis and biological activity. Spruce, L.W., Gale, J.B., Berlin, K.D., Verma, A.K., Breitman, T.R., Ji, X.H., van der Helm, D. J. Med. Chem. (1991) [Pubmed]
Discovery of thiochroman and chroman derivatives as pure antiestrogens and their structure-activity relationship. Kanbe, Y., Kim, M.H., Nishimoto, M., Ohtake, Y., Kato, N., Tsunenari, T., Taniguchi, K., Ohizumi, I., Kaiho, S., Morikawa, K., Jo, J.C., Lim, H.S., Kim, H.Y. Bioorg. Med. Chem. (2006) [Pubmed]

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