MeSH Review:
Structure-Activity Relationship
Turnbull,
Hopwood,
Gallagher,
Sakmar,
Kotsonis,
Fröhlich,
Raman,
Li,
Berg,
Gerwig,
Groehn,
Kang,
Al-Masoudi,
Taghavi-Moghadam,
Mohr,
Münch,
Schnabel,
Martásek,
Masters,
Strobel,
Poulos,
Matter,
Pfleiderer,
Schmidt,
Hardcastle,
Golding,
Griffin,
Toogood,
Raeber,
Brandner,
Klein,
Benninger,
Musahl,
Frigg,
Roeckl,
Fischer,
Weissmann,
Aguzzi,
- The glycine site of the NMDA receptor--five years on. Kemp, J.A., Leeson, P.D. Trends Pharmacol. Sci. (1993)
- Expression of P1-450 and P3-450 DNA coding sequences as enzymatically active cytochromes P-450 in mammalian cells. Battula, N., Sagara, J., Gelboin, H.V. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Transgenic and knockout mice in research on prion diseases. Raeber, A.J., Brandner, S., Klein, M.A., Benninger, Y., Musahl, C., Frigg, R., Roeckl, C., Fischer, M.B., Weissmann, C., Aguzzi, A. Brain Pathol. (1998)
- Arginine deiminase from Mycoplasma arthritidis. Structure-activity relationships among substrates and competitive inhibitors. Smith, D.W., Ganaway, R.L., Fahrney, D.E. J. Biol. Chem. (1978)
- A study of the structure-activity relationship for diazaborine inhibition of Escherichia coli enoyl-ACP reductase. Levy, C.W., Baldock, C., Wallace, A.J., Sedelnikova, S., Viner, R.C., Clough, J.M., Stuitje, A.R., Slabas, A.R., Rice, D.W., Rafferty, J.B. J. Mol. Biol. (2001)
- Synthesis and central nervous system actions of thyrotropin-releasing hormone analogues containing a dihydroorotic acid moiety. Suzuki, M., Sugano, H., Matsumoto, K., Yamamura, M., Ishida, R. J. Med. Chem. (1990)
- Novel 1-phenylcycloalkanecarboxylic acid derivatives as potential anticonvulsant agents. Calderon, S.N., Newman, A.H., Tortella, F.C. J. Med. Chem. (1991)
- Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. Suzuki, F., Shimada, J., Shiozaki, S., Ichikawa, S., Ishii, A., Nakamura, J., Nonaka, H., Kobayashi, H., Fuse, E. J. Med. Chem. (1993)
- Structure-activity studies on amphetamine analogs using drug discrimination methodology. Glennon, R.A., Young, R., Hauck, A.E., McKenney, J.D. Pharmacol. Biochem. Behav. (1984)
- Response of murine epidermis to 2,3,7,8-tetrachlorodibenzo-p-dioxin: interaction of the ah and hr loci. Knutson, J.C., Poland, A. Cell (1982)
- Structure of rhodopsin and the superfamily of seven-helical receptors: the same and not the same. Sakmar, T.P. Curr. Opin. Cell Biol. (2002)
- Designing inhibitors of cyclin-dependent kinases. Hardcastle, I.R., Golding, B.T., Griffin, R.J. Annu. Rev. Pharmacol. Toxicol. (2002)
- Platelet-activating factor antagonists. Saunders, R.N., Handley, D.A. Annu. Rev. Pharmacol. Toxicol. (1987)
- Structure-activity relationships of dopamine agonists. Cannon, J.G. Annu. Rev. Pharmacol. Toxicol. (1983)
- Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: synthesis and structure-activity relationships. Glase, S.A., Akunne, H.C., Heffner, T.G., Jaen, J.C., MacKenzie, R.G., Meltzer, L.T., Pugsley, T.A., Smith, S.J., Wise, L.D. J. Med. Chem. (1996)
- Intercalating agents with covalent bond forming capability. A novel type of potential anticancer agents. 2. Derivatives of chrysophanol and emodin. Koyama, M., Takahashi, K., Chou, T.C., Darzynkiewicz, Z., Kapuscinski, J., Kelly, T.R., Watanabe, K.A. J. Med. Chem. (1989)
- 6-Anilinouracil-based inhibitors of Bacillus subtilis DNA polymerase III: antipolymerase and antimicrobial structure-activity relationships based on substitution at uracil N3. Tarantino, P.M., Zhi, C., Gambino, J.J., Wright, G.E., Brown, N.C. J. Med. Chem. (1999)
- Synthesis, tubulin binding, antineoplastic evaluation, and structure-activity relationship of oncodazole analogues. Kruse, L.I., Ladd, D.L., Harrsch, P.B., McCabe, F.L., Mong, S.M., Faucette, L., Johnson, R. J. Med. Chem. (1989)
- Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation. Natarajan, A., Guo, Y., Harbinski, F., Fan, Y.H., Chen, H., Luus, L., Diercks, J., Aktas, H., Chorev, M., Halperin, J.A. J. Med. Chem. (2004)
- Structure-activity relationships of gastrointestinal hormones: motilin, GIP, and [27-TYR]CCK-PZ. Yajima, H., Kai, Y., Ogawa, H., Kubota, M., Mori, Y. Gastroenterology (1977)
- A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. Fenteany, G., Standaert, R.F., Reichard, G.A., Corey, E.J., Schreiber, S.L. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Tumorigenicity in vivo and induction of mutagenesis and DNA repair in vitro by aclacinomycin A and marcellomycin: structure-activity relationship and predictive value of short-term tests. Westendorf, J., Marquardt, H., Ketkar, M.B., Mohr, U., Marquardt, H. Cancer Res. (1983)
- Studies on the specificity of the tetrapyrrole substrate for human biliverdin-IXalpha reductase and biliverdin-IXbeta reductase. Structure-activity relationships define models for both active sites. Cunningham, O., Dunne, A., Sabido, P., Lightner, D., Mantle, T.J. J. Biol. Chem. (2000)
- Substrate specificity and structure-activity relationships of gentamicin acetyltransferase I. The dependence of antibiotic resistance upon substrate Vmax/Km values. Williams, J.W., Northrop, D.B. J. Biol. Chem. (1978)
- Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimer. Tzeng, E., Billiar, T.R., Robbins, P.D., Loftus, M., Stuehr, D.J. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Antiproliferative and angiostatic activity of suramin analogues. Firsching, A., Nickel, P., Mora, P., Allolio, B. Cancer Res. (1995)
- Alpha-interferon structure and natural killer cell stimulatory activity. Li, B.L., Zhao, X.X., Liu, X.Y., Kim, H.S., Raska, K., Ortaldo, J.R., Schwartz, B., Pestka, S. Cancer Res. (1990)
- Steroid induction of delta-aminolevulinic acid synthase and porphyrins in liver. Structure-activity studies and the permissive effects of hormones on the induction process. Sassa, S., Bradlow, H.L., Kappas, A. J. Biol. Chem. (1979)
- Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogs at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase. Cornfield, L.J., Lambert, G., Arvidsson, L.E., Mellin, C., Vallgårda, J., Hacksell, U., Nelson, D.L. Mol. Pharmacol. (1991)
- Mouse skin tumor-initiating activity of 5-, 7-, and 12-methyl- and fluorine-substituted benz[a]anthracenes. Wood, A.W., Levin, W., Chang, R.L., Conney, A.H., Slaga, T.J., O'Malley, R.F., Newman, M.S., Buhler, D.R., Jerina, D.M. J. Natl. Cancer Inst. (1982)
- Structure-activity relationships of heparin. Independence of heparin charge density and antithrombin-binding domains in thrombin inhibition by antithrombin and heparin cofactor II. Hurst, R.E., Poon, M.C., Griffith, M.J. J. Clin. Invest. (1983)
- A novel membrane receptor with high affinity for lysosphingomyelin and sphingosine 1-phosphate in atrial myocytes. Bünemann, M., Liliom, K., Brandts, B.K., Pott, L., Tseng, J.L., Desiderio, D.M., Sun, G., Miller, D., Tigyi, G. EMBO J. (1996)
- Differentiation of Friend erythroleukemia cells induced by benzodiazepines. Wang, J.K., Morgan, J.I., Spector, S. Proc. Natl. Acad. Sci. U.S.A. (1984)
- A strategy for rapid sequencing of heparan sulfate and heparin saccharides. Turnbull, J.E., Hopwood, J.J., Gallagher, J.T. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Peptide transport by the multidrug resistance protein MRP1. de Jong, M.C., Slootstra, J.W., Scheffer, G.L., Schroeijers, A.B., Puijk, W.C., Dinkelberg, R., Kool, M., Broxterman, H.J., Meloen, R.H., Scheper, R.J. Cancer Res. (2001)
- Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents. Szewczuk, L.M., Forti, L., Stivala, L.A., Penning, T.M. J. Biol. Chem. (2004)
- Structural basis for pterin antagonism in nitric-oxide synthase. Development of novel 4-oxo-pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterin. Kotsonis, P., Fröhlich, L.G., Raman, C.S., Li, H., Berg, M., Gerwig, R., Groehn, V., Kang, Y., Al-Masoudi, N., Taghavi-Moghadam, S., Mohr, D., Münch, U., Schnabel, J., Martásek, P., Masters, B.S., Strobel, H., Poulos, T., Matter, H., Pfleiderer, W., Schmidt, H.H. J. Biol. Chem. (2001)
- Cyclin-dependent kinase inhibitors for treating cancer. Toogood, P.L. Medicinal research reviews. (2001)
- Anticancer multidrug resistance mediated by MRP1: recent advances in the discovery of reversal agents. Boumendjel, A., Baubichon-Cortay, H., Trompier, D., Perrotton, T., Di Pietro, A. Medicinal research reviews. (2005)
- Radiolabeled cholinesterase substrates: in vitro methods for determining structure-activity relationships and identification of a positron emission tomography radiopharmaceutical for in vivo measurement of butyrylcholinesterase activity. Snyder, S.E., Gunupudi, N., Sherman, P.S., Butch, E.R., Skaddan, M.B., Kilbourn, M.R., Koeppe, R.A., Kuhl, D.E. J. Cereb. Blood Flow Metab. (2001)
- Synthesis and Structure-Activity Relationship Study of Antidiabetic Penta-O-galloyl-d-glucopyranose and Its Analogues. Ren, Y., Himmeldirk, K., Chen, X. J. Med. Chem. (2006)
- Identification and specificity studies of small-molecule ligands for SH3 protein domains. Inglis, S.R., Stojkoski, C., Branson, K.M., Cawthray, J.F., Fritz, D., Wiadrowski, E., Pyke, S.M., Booker, G.W. J. Med. Chem. (2004)
- Design, synthesis, and biological evaluation of biotin conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid for the isolation of the protein targets. Honda, T., Janosik, T., Honda, Y., Han, J., Liby, K.T., Williams, C.R., Couch, R.D., Anderson, A.C., Sporn, M.B., Gribble, G.W. J. Med. Chem. (2004)
- Membrane-Induced Structure of Scyliorhinin I: A Dual NK1/NK2 Agonist. Dike, A., Cowsik, S.M. Biophys. J. (2005)