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Chemical Compound Review:

HyTEMPO

Synonyms: tempol, HOTMP, Tanol, TMPN, Nitroxyl 2, ...

Cotrim, A.P. et al., García-Calderó, H. et al.

James B. Mitchell, Murali C. Krishna, Ana P. Cotrim, Anastasia L. Sowers, Bruce J. Baum, Fuminori Hyodo, Ken-Ichiro Matsumoto, John A. Cook,

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Associations of HyTEMPO with other chemical compounds

Intracellular reduction of Tempol to the nonradioprotective hydroxylamine as assessed by MRI was 2-fold faster in tumor compared with salivary glands or muscle [1].
Tempol reduced superoxide content and increased NO both in SEC and cirrhotic livers [2].

References

Differential radiation protection of salivary glands versus tumor by Tempol with accompanying tissue assessment of Tempol by magnetic resonance imaging. Cotrim, A.P., Hyodo, F., Matsumoto, K., Sowers, A.L., Cook, J.A., Baum, B.J., Krishna, M.C., Mitchell, J.B. Clin. Cancer Res. (2007) [Pubmed]
Tempol administration, a superoxide dismutase mimetic, reduces hepatic vascular resistance and portal pressure in cirrhotic rats. García-Calderó, H., Rodríguez-Vilarrupla, A., Gracia-Sancho, J., Diví, M., Laviña, B., Bosch, J., García-Pagán, J.C. J. Hepatol. (2011) [Pubmed]

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