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Chemical Compound Review:

Superoxide

Synonyms: Hyperoxid, HYPEROXIDE, superoxyde, dioxidanidyl, dioxide(1-), ...

Lin, C.L. et al., Chen, J. et al., Rottenberg, H. et al.

Yu-Hsia Kuo, Jih-Yang Ko, Feng-Sheng Wang, Chun-Liang Lin, Jeng-Yi Wang, Hagai Rottenberg, Raul Covian, Bernard L. Trumpower, Kameswaran Surendran, Yu-Ting Huang,

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Associations of Superoxide with other chemical compounds

These findings suggest a dual regulatory mechanism through the PX domain of p40(phox); its interaction with the actin cytoskeleton may stabilize NADPH oxidase in resting cells, and its binding of PtdIns (3)P potentiates superoxide production upon agonist stimulation [1].
Immunohistological observation revealed that superoxide dismutase treatment abrogated diabetes-induced caspase-3 cleavage and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end-labeling (TUNEL) and increased Wnt5a/beta-catenin expression in renal glomeruli [2].
When the membrane potential was further increased, by the addition of nigericin or by the imposition of a diffusion potential, the rate of generation of superoxide was further accelerated and approached the rate obtained with antimycin [3].

References

Characterization of a mutation in the Phox homology domain of the NADPH oxidase component p40phox identifies a mechanism for negative regulation of superoxide production. Chen, J., He, R., Minshall, R.D., Dinauer, M.C., Ye, R.D. J. Biol. Chem. (2007) [Pubmed]
Superoxide destabilization of beta-catenin augments apoptosis of high-glucose-stressed mesangial cells. Lin, C.L., Wang, J.Y., Ko, J.Y., Surendran, K., Huang, Y.T., Kuo, Y.H., Wang, F.S. Endocrinology (2008) [Pubmed]
Membrane potential greatly enhances superoxide generation by the cytochrome bc1 complex reconstituted into phospholipid vesicles. Rottenberg, H., Covian, R., Trumpower, B.L. J. Biol. Chem. (2009) [Pubmed]

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