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Chemical Compound Review:

CHEMBL19497 ethyl2-[2-(4-chlorophenyl)-5- (2-furyl)-1...

Synonyms: SureCN10505797, TA-1801, TA 1801, AC1L3F64, 88352-44-7

Kaji, H. et al., Kobayashi, T. et al.

Kaji, Kume,

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High impact information on TA 1801

The first metabolic reaction for TA-1801 was hydrolysis of the ester linkage [1].

Analytical, diagnostic and therapeutic context of TA 1801

The metabolism of ethyl 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetate (TA-1801), a potent hypolipidemic agent, was studied in humans after oral administration and compared with that found in rats, rabbits, and dogs previously [2].

References

Metabolism of ethyl 2-(4-chlorophenyl)-5-(2-furyl)-oxazole-4-acetate, a new hypolipidemic agent, in the rat, rabbit, and dog. Glucuronidation of carboxyl group and cleavage of furan ring. Kobayashi, T., Ando, H., Sugihara, J., Harigaya, S. Drug Metab. Dispos. (1987) [Pubmed]
Glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid (TA-1801A) in humans: species differences in liver and intestinal microsomes. Kaji, H., Kume, T. Drug Metab. Pharmacokinet. (2005) [Pubmed]

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