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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

Cranoc     (E,3S,5R)-7-[3-(4- fluorophenyl)-1-propan-2...

Synonyms: Fluvas, Lescol, Canef, fluvastatin, Fluvastatina, ...
 
 
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High impact information on Cranoc

  • About the same was observed for the statin effect on CYP2C9 activity, except that F was a strong inhibitor of this activity (IC(50) value: 4 microM) [1].
  • Except P, the other five statins were stronger inhibitors of the CYP2C19 activity with IC(50) values around 200 microM and the same holds for the effect of A, C and F on the CYP2D6 activity [1].
 

Anatomical context of Cranoc

References

  1. Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Cohen, L.H., van Leeuwen, R.E., van Thiel, G.C., van Pelt, J.F., Yap, S.H. Biopharmaceutics & drug disposition. (2000) [Pubmed]
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