Gene Review:
CYP2C19 - cytochrome P450, family 2, subfamily C,...
Homo sapiens
Synonyms:
(R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, CPCJ, CYP2C, ...
Kim,
Begg,
Grime,
Mountfield,
Thomsen,
Kenny,
George,
Dryer,
Wilkinson,
Shimada,
Saleh,
Leodolter,
Malfertheiner,
Smeaton,
Asahi,
Hofmann,
Morse,
Knight,
McGinnity,
Riedel,
Hirsch,
D'Aquila,
Haas,
Jørgensen,
Klotz,
Merigan,
Nakamura,
Schöwel,
Hatanaka,
Gardiner,
Riley,
Guengerich,
Schulz-Utermoehl,
Pollard,
Weiss,
Komatsu,
Schwab,
Schaeffeler,
Burhenne,
Haefeli,
Zaphiropoulos,
Guernsey,
Treiber,
Berry,
Shafer,
Donahue,
Mikus,
Shimada,
Rengelshausen,
Drzewinska,
Hender,
Cribb,
Hansen,
Ohyama,
Nakajima,
Madsen,
Labbe,
Clifford,
De Gruttola,
Ding,
Robbins,
Yokoi,
Yamazaki,
Tesch,
- Ticlopidine inhibition of phenytoin metabolism mediated by potent inhibition of CYP2C19. Donahue, S.R., Flockhart, D.A., Abernethy, D.R., Ko, J.W. Clin. Pharmacol. Ther. (1997)
- Clinical significance of the cytochrome P450 2C19 genetic polymorphism. Desta, Z., Zhao, X., Shin, J.G., Flockhart, D.A. Clinical pharmacokinetics. (2002)
- Engineering human cytochrome P450 enzymes into catalytically self-sufficient chimeras using molecular Lego. Dodhia, V.R., Fantuzzi, A., Gilardi, G. J. Biol. Inorg. Chem. (2006)
- Role of polymorphic human cytochrome P450 enzymes in estrone oxidation. Cribb, A.E., Knight, M.J., Dryer, D., Guernsey, J., Hender, K., Tesch, M., Saleh, T.M. Cancer Epidemiol. Biomarkers Prev. (2006)
- Cytochrome P450 2C is an EDHF synthase in coronary arteries. Fisslthaler, B., Popp, R., Kiss, L., Potente, M., Harder, D.R., Fleming, I., Busse, R. Nature (1999)
- Pharmacogenetics, drug-metabolizing enzymes, and clinical practice. Gardiner, S.J., Begg, E.J. Pharmacol. Rev. (2006)
- Effects of omeprazole on intragastric pH and plasma gastrin are dependent on the CYP2C19 polymorphism. Sagar, M., Tybring, G., Dahl, M.L., Bertilsson, L., Seensalu, R. Gastroenterology (2000)
- Conversion of the HIV protease inhibitor nelfinavir to a bioactive metabolite by human liver CYP2C19. Hirani, V.N., Raucy, J.L., Lasker, J.M. Drug Metab. Dispos. (2004)
- CYP2B6 and CYP2C19 as the major enzymes responsible for the metabolism of selegiline, a drug used in the treatment of Parkinson's disease, as revealed from experiments with recombinant enzymes. Hidestrand, M., Oscarson, M., Salonen, J.S., Nyman, L., Pelkonen, O., Turpeinen, M., Ingelman-Sundberg, M. Drug Metab. Dispos. (2001)
- Clinical importance of non-genetic and genetic cytochrome P450 function tests in liver disease. Tanaka, E. Journal of clinical pharmacy and therapeutics. (1998)
- Esomeprazole-induced healing of gastroesophageal reflux disease is unrelated to the genotype of CYP2C19: evidence from clinical and pharmacokinetic data. Schwab, M., Klotz, U., Hofmann, U., Schaeffeler, E., Leodolter, A., Malfertheiner, P., Treiber, G. Clin. Pharmacol. Ther. (2005)
- RNA molecules containing exons originating from different members of the cytochrome P450 2C gene subfamily (CYP2C) in human epidermis and liver. Zaphiropoulos, P.G. Nucleic Acids Res. (1999)
- Potent cytochrome P450 2C19 genotype-related interaction between voriconazole and the cytochrome P450 3A4 inhibitor ritonavir. Mikus, G., Schöwel, V., Drzewinska, M., Rengelshausen, J., Ding, R., Riedel, K.D., Burhenne, J., Weiss, J., Thomsen, T., Haefeli, W.E. Clin. Pharmacol. Ther. (2006)
- Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese patients with epilepsy. Odani, A., Hashimoto, Y., Otsuki, Y., Uwai, Y., Hattori, H., Furusho, K., Inui, K. Clin. Pharmacol. Ther. (1997)
- Thalidomide metabolism by the CYP2C subfamily. Ando, Y., Fuse, E., Figg, W.D. Clin. Cancer Res. (2002)
- The role of CYP2C in the in vitro bioactivation of the contraceptive steroid desogestrel. Gentile, D.M., Verhoeven, C.H., Shimada, T., Back, D.J. J. Pharmacol. Exp. Ther. (1998)
- Evaluation of time-dependent cytochrome P450 inhibition using cultured human hepatocytes. McGinnity, D.F., Berry, A.J., Kenny, J.R., Grime, K., Riley, R.J. Drug Metab. Dispos. (2006)
- Metabolic characterization of the major human small intestinal cytochrome p450s. Obach, R.S., Zhang, Q.Y., Dunbar, D., Kaminsky, L.S. Drug Metab. Dispos. (2001)
- Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs. Klose, T.S., Blaisdell, J.A., Goldstein, J.A. J. Biochem. Mol. Toxicol. (1999)
- The effect of omeprazole pretreatment on acetaminophen metabolism in rapid and slow metabolizers of S-mephenytoin. Sarich, T., Kalhorn, T., Magee, S., al-Sayegh, F., Adams, S., Slattery, J., Goldstein, J., Nelson, S., Wright, J. Clin. Pharmacol. Ther. (1997)
- Effect of growth hormone on hepatic cytochrome P450 activity in healthy elderly men. Jürgens, G., Lange, K.H., Reuther, L.Ø., Rasmussen, B.B., Brøsen, K., Christensen, H.R. Clin. Pharmacol. Ther. (2002)
- Role of human cytochrome P450 3A4 in metabolism of medroxyprogesterone acetate. Kobayashi, K., Mimura, N., Fujii, H., Minami, H., Sasaki, Y., Shimada, N., Chiba, K. Clin. Cancer Res. (2000)
- Extraadrenal 21-hydroxylation by CYP2C19 and CYP3A4: effect on 21-hydroxylase deficiency. Gomes, L.G., Huang, N., Agrawal, V., Mendonça, B.B., Bachega, T.A., Miller, W.L. J. Clin. Endocrinol. Metab. (2009)
- Production of inhibitory polyclonal antibodies against cytochrome P450s. Ng, P.S., Imaoka, S., Hiroi, T., Osada, M., Niwa, T., Kamataki, T., Funae, Y. Drug Metab. Pharmacokinet. (2003)
- Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter. Chen, Y., Ferguson, S.S., Negishi, M., Goldstein, J.A. Mol. Pharmacol. (2003)
- Capillary electrophoresis to assess drug metabolism induced in vitro using single CYP450 enzymes (Supersomes): application to the chiral metabolism of mephenytoin and methadone. Prost, F., Thormann, W. Electrophoresis (2003)
- Induction of cytochrome P450 enzymes in cultured precision-cut human liver slices. Edwards, R.J., Price, R.J., Watts, P.S., Renwick, A.B., Tredger, J.M., Boobis, A.R., Lake, B.G. Drug Metab. Dispos. (2003)
- Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli. Yamazaki, H., Nakamura, M., Komatsu, T., Ohyama, K., Hatanaka, N., Asahi, S., Shimada, N., Guengerich, F.P., Shimada, T., Nakajima, M., Yokoi, T. Protein Expr. Purif. (2002)
- Combined analysis of inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1, microsomal epoxide hydrolase, and cytochrome P450 enzymes as modulators of bladder cancer risk. Brockmöller, J., Cascorbi, I., Kerb, R., Roots, I. Cancer Res. (1996)
- Pharmacogenetics of long-term responses to antiretroviral regimens containing Efavirenz and/or Nelfinavir: an Adult Aids Clinical Trials Group Study. Haas, D.W., Smeaton, L.M., Shafer, R.W., Robbins, G.K., Morse, G.D., Labbe, L., Wilkinson, G.R., Clifford, D.B., D'Aquila, R.T., De Gruttola, V., Pollard, R.B., Merigan, T.C., Hirsch, M.S., George, A.L., Donahue, J.P., Kim, R.B. J. Infect. Dis. (2005)
- Identification of the human P450 enzymes involved in lansoprazole metabolism. Pearce, R.E., Rodrigues, A.D., Goldstein, J.A., Parkinson, A. J. Pharmacol. Exp. Ther. (1996)
- Different contributions of cytochrome P450 2C19 and 3A4 in the oxidation of omeprazole by human liver microsomes: effects of contents of these two forms in individual human samples. Yamazaki, H., Inoue, K., Shaw, P.M., Checovich, W.J., Guengerich, F.P., Shimada, T. J. Pharmacol. Exp. Ther. (1997)
- Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms. Coller, J.K., Somogyi, A.A., Bochner, F. British journal of clinical pharmacology. (1999)
- Influence of azimilide on CYP2C19-mediated metabolism. El Mouelhi, M., Worley, D.J., Kuzmak, B., Destefano, A.J., Thompson, G.A. Journal of clinical pharmacology. (2004)
- Selective and potent inhibition of human CYP2C19 activity by a conformationally targeted antipeptide antibody. Schulz-Utermoehl, T., Mountfield, R.J., Madsen, K., Jørgensen, P.N., Hansen, K.T. Drug Metab. Dispos. (2000)