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Chemical Compound Review:

AG-G-87821 2,4-dichlorohexa-2,4- dienedioic acid

Synonyms: CTK1A7644, CTK2H7888, AC1L4F9J, 22752-97-2, 72945-11-0

Benndorf, D. et al., Solyanikova, I.P. et al., Vedler, E. et al.

Vedler, Kõiv, Heinaru,

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Disease relevance of C03918

The catalytic properties indicate that efficient cycloisomerization of 3-chloro- and 2,4-dichloro-cis,cis-muconate might have evolved independently among gram-positive and gram-negative bacteria [1].

High impact information on C03918

We showed that the pEST4011 tfdR gene product activates the expression of the tfdCB operon and the effector molecule for TfdR is 2,4-dichloro-cis,cis-muconate [2].
Both enzymes catalyse the conversion of 3,5-dichlorocatechol to 2,4-dichloro-cis,cis-muconate indicating that biodegradation is a major mechanism of resistance in the detoxifying bacterium D. acidovorans MC1 [3].

References

Characterization of muconate and chloromuconate cycloisomerase from Rhodococcus erythropolis 1CP: indications for functionally convergent evolution among bacterial cycloisomerases. Solyanikova, I.P., Maltseva, O.V., Vollmer, M.D., Golovleva, L.A., Schlömann, M. J. Bacteriol. (1995) [Pubmed]
TfdR, the LysR-type transcriptional activator, is responsible for the activation of the tfdCB operon of Pseudomonas putida 2, 4-dichlorophenoxyacetic acid degradative plasmid pEST4011. Vedler, E., Kõiv, V., Heinaru, A. Gene (2000) [Pubmed]
Assimilatory detoxification of herbicides by Delftia acidovorans MC1: induction of two chlorocatechol 1,2-dioxygenases as a response to chemostress. Benndorf, D., Babel, W. Microbiology (Reading, Engl.) (2002) [Pubmed]

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