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Chemical Compound Review:

Lopac-D-132 3-[2-(dipropylamino)ethyl]- 1H-indole-5...

Synonyms: Dipropyl-5-CT, SureCN8891095, DP-5-CT, DP5CT, CCG-204501, ...

Tsou, A.P. et al., Yocca, F.D. et al., Shen, C. et al., Eison, A.S. et al., Wallis, D.I. et al.

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High impact information on DP-5-CT

Concentration-response curves were generated for inhibition of forskolin-stimulated adenylyl cyclase activity by 5-HT and the selective 5-HT1A agonist N,N-dipropyl-5-carboxamidotryptamine (DP-5-CT) [1].
Adenylyl cyclase activity in CHO-K1 cells transiently transfected with GP2-7 was stimulated by several analogues of 5-HT with the following order of potency: 5-CT > 5-HT = 5-MeOT > dipropyl-5-CT > 8-OH-DPAT [2].
4. Dipropyl-5-CT selectively depressed MSR and CON SLOW (IC50 90-170 nM) but was less potent than 5-CT [3].

Anatomical context of DP-5-CT

The selective 5-HT1A receptor agonist N,N-dipropyl-5-CT (DP-5-CT) also induced hindlimb scratching while the selective 5-HT1D receptor agonist, sumatriptan, did not [4].

Analytical, diagnostic and therapeutic context of DP-5-CT

This hypothesis was tested using N,N-dipropyl-5-carboxamidotryptamine-stimulated guanosine-5'-O-(3-thio)triphosphate ([(35)S]GTPgammaS) binding assessed by autoradiography [5].

References

Lack of apparent receptor reserve at postsynaptic 5-hydroxytryptamine1A receptors negatively coupled to adenylyl cyclase activity in rat hippocampal membranes. Yocca, F.D., Iben, L., Meller, E. Mol. Pharmacol. (1992) [Pubmed]
Cloning and expression of a 5-hydroxytryptamine7 receptor positively coupled to adenylyl cyclase. Tsou, A.P., Kosaka, A., Bach, C., Zuppan, P., Yee, C., Tom, L., Alvarez, R., Ramsey, S., Bonhaus, D.W., Stefanich, E. J. Neurochem. (1994) [Pubmed]
FAST and SLOW ipsilateral and contralateral spinal reflexes in the neonate rat are modulated by 5-HT. Wallis, D.I., Wu, J. Gen. Pharmacol. (1992) [Pubmed]
Peripheral 5-carboxamidotryptamine induces hindlimb scratching by stimulating 5-HT1A receptors in rats. Eison, A.S., Wright, R.N., Freeman, R. Life Sci. (1992) [Pubmed]
Repeated treatment with antidepressants differentially alters 5-HT1A agonist-stimulated [35S]GTP gamma S binding in rat brain regions. Shen, C., Li, H., Meller, E. Neuropharmacology (2002) [Pubmed]

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