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Chemical Compound Review

serotonin     3-(2-aminoethyl)-1H-indol-5-ol

Synonyms: Antemoqua, Antemovis, Enteramin, Enteramine, Hippophain, ...
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Disease relevance of serotonin


Psychiatry related information on serotonin


High impact information on serotonin


Chemical compound and disease context of serotonin


Biological context of serotonin


Anatomical context of serotonin


Associations of serotonin with other chemical compounds


Gene context of serotonin


Analytical, diagnostic and therapeutic context of serotonin


  1. Cushing's syndrome due to ectopic ACTH production by a carcinoid tumor not producing serotonin. Santelices, R., Bobadilla, E., Pineda, G., Hirsh, L., Silva, J.E. N. Engl. J. Med. (1983) [Pubmed]
  2. Serotonin in essential myoclonus. Omenn, G.S., Bird, T.D., Johnsen, S.D. N. Engl. J. Med. (1977) [Pubmed]
  3. Divergent effects of serotonin on coronary-artery dimensions and blood flow in patients with coronary atherosclerosis and control patients. Golino, P., Piscione, F., Willerson, J.T., Cappelli-Bigazzi, M., Focaccio, A., Villari, B., Indolfi, C., Russolillo, E., Condorelli, M., Chiariello, M. N. Engl. J. Med. (1991) [Pubmed]
  4. Heparin-associated thrombocytopenia. Cines, D.B., Kaywin, P., Bina, M., Tomaski, A., Schreiber, A.D. N. Engl. J. Med. (1980) [Pubmed]
  5. Serotonin and acute ischemic heart disease. Hillis, L.D., Lange, R.A. N. Engl. J. Med. (1991) [Pubmed]
  6. Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis. Nocito, A., Dahm, F., Jochum, W., Jang, J.H., Georgiev, P., Bader, M., Renner, E.L., Clavien, P.A. Gastroenterology (2007) [Pubmed]
  7. Expression of serotonin receptors in human hepatocellular cancer. Soll, C., Riener, M.O., Oberkofler, C.E., Hellerbrand, C., Wild, P.J., Deoliveira, M.L., Clavien, P.A. Clin. Cancer Res. (2012) [Pubmed]
  8. Huntington's chorea. Changes in neurotransmitter receptors in the brain. Enna, S.J., Bird, E.D., Bennett, J.P., Bylund, D.B., Yamamura, H.I., Iversen, L.L., Snyder, S.H. N. Engl. J. Med. (1976) [Pubmed]
  9. Blood serotonin levels in the attention-deficit disorder. Haslam, R.H., Dalby, J.T. N. Engl. J. Med. (1983) [Pubmed]
  10. Presynaptic serotonin receptor-mediated response in mice attenuated by antidepressant drugs and electroconvulsive shock. Goodwin, G.M., De Souza, R.J., Green, A.R. Nature (1985) [Pubmed]
  11. "Serotonin depression"--a biochemical subgroup within the affective disorders? Asberg, M., Thorén, P., Träskman, L., Bertilsson, L., Ringberger, V. Science (1976) [Pubmed]
  12. Vulnerability to lasting anxiogenic effects of brief exposure to predator stimuli: sex, serotonin and other factors-relevance to PTSD. Adamec, R., Holmes, A., Blundell, J. Neurosci. Biobehav. Rev (2008) [Pubmed]
  13. FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Ye, W., Shimamura, K., Rubenstein, J.L., Hynes, M.A., Rosenthal, A. Cell (1998) [Pubmed]
  14. Synapse-specific, long-term facilitation of aplysia sensory to motor synapses: a function for local protein synthesis in memory storage. Martin, K.C., Casadio, A., Zhu, H., Yaping, E., Rose, J.C., Chen, M., Bailey, C.H., Kandel, E.R. Cell (1997) [Pubmed]
  15. Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. Max, M.B., Lynch, S.A., Muir, J., Shoaf, S.E., Smoller, B., Dubner, R. N. Engl. J. Med. (1992) [Pubmed]
  16. Effect of intracoronary serotonin on coronary vessels in patients with stable angina and patients with variant angina. McFadden, E.P., Clarke, J.G., Davies, G.J., Kaski, J.C., Haider, A.W., Maseri, A. N. Engl. J. Med. (1991) [Pubmed]
  17. Long-term therapy of myoclonus and other neurologic disorders with L-5-hydroxytryptophan and carbidopa. Van Woert, M.H., Rosenbaum, D., Howieson, J., Bowers, M.B. N. Engl. J. Med. (1977) [Pubmed]
  18. Platelet function in essential thrombocythemia. Decreased epinephrine responsiveness associated with a deficiency of platelet alpha-adrenergic receptors. Kaywin, P., McDonough, M., Insel, P.A., Shattil, S.J. N. Engl. J. Med. (1978) [Pubmed]
  19. Hyperphagia and increased growth in rats after intraventricular injection of 5,7-dihydroxytryptamine. Saller, C.F., Stricker, E.M. Science (1976) [Pubmed]
  20. Monoamine changes in the brain of cats during slow-wave sleep. Kovacević, R., Radulovacki, M. Science (1976) [Pubmed]
  21. A study of protein phosphorylation in shape change and Ca++-dependent serotonin release by blood platelets. Bennett, W.F., Belville, J.S., Lynch, G. Cell (1979) [Pubmed]
  22. Circadian clock in Xenopus eye controlling retinal serotonin N-acetyltransferase. Besharse, J.C., Iuvone, P.M. Nature (1983) [Pubmed]
  23. Persistent and transcriptionally-dependent increase in protein phosphorylation in long-term facilitation of Aplysia sensory neurons. Sweatt, J.D., Kandel, E.R. Nature (1989) [Pubmed]
  24. Intracellular studies showing modulation of facial motoneurone excitability by serotonin. VanderMaelen, C.P., Aghajanian, G.K. Nature (1980) [Pubmed]
  25. Brain neurotransmitters in dystonia musculorum deformans. Hornykiewicz, O., Kish, S.J., Becker, L.E., Farley, I., Shannak, K. N. Engl. J. Med. (1986) [Pubmed]
  26. Cyproheptadine-induced remission of Cushing's disease. Krieger, D.T., Amorosa, L., Linick, F. N. Engl. J. Med. (1975) [Pubmed]
  27. Potentiation of central reward by localised perfusion of acetylcholine and 5-hydroxytryptamine. Redgrave, P., Horrell, R.I. Nature (1976) [Pubmed]
  28. Central serotonergic nerves project to the pial vessels of the brain. Edvinsson, L., Degueurce, A., Duverger, D., MacKenzie, E.T., Scatton, B. Nature (1983) [Pubmed]
  29. Differential circadian rhythms in pineal and hypothalamic 5-HT induced by artificial photoperiods or melatonin. Yates, C.A., Herbert, J. Nature (1976) [Pubmed]
  30. Metabolite considerations in the in vivo quantification of serotonin transporters using 11C-DASB and PET in humans. Parsey, R.V., Ojha, A., Ogden, R.T., Erlandsson, K., Kumar, D., Landgrebe, M., Van Heertum, R., Mann, J.J. J. Nucl. Med. (2006) [Pubmed]
  31. Serotonin receptors antagonistically modulate Caenorhabditis elegans longevity. Murakami, H., Murakami, S. Aging. Cell (2007) [Pubmed]
  32. Glucocorticoid receptor antagonists hasten and augment neurochemical responses to a selective serotonin reuptake inhibitor antidepressant. Johnson, D.A., Grant, E.J., Ingram, C.D., Gartside, S.E. Biol. Psychiatry (2007) [Pubmed]
  33. 5-HT 1B receptor-mediated serotoninergic modulation of methylphenidate-induced locomotor activation in rats. Borycz, J., Zapata, A., Quiroz, C., Volkow, N.D., Ferré, S. Neuropsychopharmacology (2008) [Pubmed]
  34. MDMA induces EPSP-Spike potentiation in rat ventral hippocampus in vitro via serotonin and noradrenaline release and coactivation of 5-HT4 and beta1 receptors. Mlinar, B., Mascalchi, S., Morini, R., Giachi, F., Corradetti, R. Neuropsychopharmacology (2008) [Pubmed]
  35. Senescence-induced serotonin biosynthesis and its role in delaying senescence in rice leaves. Kang, K., Kim, Y.S., Park, S., Back, K. Plant Physiol. (2009) [Pubmed]
  36. Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene. Nonogaki, K., Strack, A.M., Dallman, M.F., Tecott, L.H. Nat. Med. (1998) [Pubmed]
  37. Localization and dynamic regulation of biogenic amine transporters in the mammalian central nervous system. Hoffman, B.J., Hansson, S.R., Mezey, E., Palkovits, M. Frontiers in neuroendocrinology. (1998) [Pubmed]
  38. The involvement of serotonin in regulation of pituitary-adrenocortical function. Fuller, R.W. Frontiers in neuroendocrinology. (1992) [Pubmed]
  39. Mutations in the dopa decarboxylase gene affect learning in Drosophila. Tempel, B.L., Livingstone, M.S., Quinn, W.G. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  40. Estradiol induces expression of 5-hydroxytryptamine (5-HT) 4, 5-HT5, and 5-HT6 receptor messenger ribonucleic acid in rat anterior pituitary cell aggregates and allows prolactin release via the 5-HT4 receptor. Papageorgiou, A., Denef, C. Endocrinology (2007) [Pubmed]
  41. Serotonin modulates the response of embryonic thalamocortical axons to netrin-1. Bonnin, A., Torii, M., Wang, L., Rakic, P., Levitt, P. Nat. Neurosci. (2007) [Pubmed]
  42. Molecular genetics of the platelet serotonin system in first-degree relatives of patients with autism. Cross, S., Kim, S.J., Weiss, L.A., Delahanty, R.J., Sutcliffe, J.S., Leventhal, B.L., Cook, E.H., Veenstra-Vanderweele, J. Neuropsychopharmacology (2008) [Pubmed]
  43. Serotonin and pulmonary hypertension--from bench to bedside? MacLean, M.R., Dempsie, Y. Curr. Opin. Pharmacol (2009) [Pubmed]
  44. Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation. Dash, P.K., Hochner, B., Kandel, E.R. Nature (1990) [Pubmed]
  45. Some neurons of the rat central nervous system contain aromatic-L-amino-acid decarboxylase but not monoamines. Jaeger, C.B., Teitelman, G., Joh, T.H., Albert, V.R., Park, D.H., Reis, D.J. Science (1983) [Pubmed]
  46. Entamoeba histolytica causes intestinal secretion: role of serotonin. McGowan, K., Kane, A., Asarkof, N., Wicks, J., Guerina, V., Kellum, J., Baron, S., Gintzler, A.R., Donowitz, M. Science (1983) [Pubmed]
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