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Chemical Compound Review:

Lipid Y [(2R,3R,4R,5R,6R)-3-[[(3R)- 3...

Synonyms: AC1L4NDS

Brozek, K.A. et al., Takayama, K. et al.

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Disease relevance of Lipid Y

Certain phosphatidylglycerol-deficient mutants of Escherichia coli accumulate two fatty acylated monosaccharides related to lipid A biosynthesis that have been identified as 2,3-diacylglucosamine 1-phosphate (lipid X) and triacylglucosamine 1-phosphate (lipid Y) (Raetz, C. R. H. (1984) Rev. Infect. Dis. 6, 463-472) [1].

High impact information on Lipid Y

Presumably, lipid Y is synthesized from X by a selective acylation reaction [2].

References

Biosynthesis of lipid A precursors in Escherichia coli. A membrane-bound enzyme that transfers a palmitoyl residue from a glycerophospholipid to lipid X. Brozek, K.A., Bulawa, C.E., Raetz, C.R. J. Biol. Chem. (1987) [Pubmed]
Glucosamine-derived phospholipids in Escherichia coli. Structure and chemical modification of a triacyl glucosamine 1-phosphate found in a phosphatidylglycerol-deficient mutant. Takayama, K., Qureshi, N., Mascagni, P., Anderson, L., Raetz, C.R. J. Biol. Chem. (1983) [Pubmed]

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