The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

msbB  -  {kdo)2-(lauroyl)-lipid iva acyltransferase

Escherichia coli

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of msbB


High impact information on msbB


Chemical compound and disease context of msbB

  • Two lipid A structural variants obtained from Porphyromonas gingivalis designated PgLPS(1435/1449) and PgLPS(1690) as well as LPS obtained from Escherichia coli wild type and an E. coli msbB mutant (missing myristic acid in the lipid A) were examined [1].
  • However, the first seven enzymes of E. coli lipid A biosynthesis, leading from UDP-GlcNAc to the phosphorylated intermediate, 2-keto-3-deoxyoctulosonate (Kdo2)-lipid IVA, are present in R. leguminosarum [11].
  • Over the past few years progress has been made in identifying the molecular mechanisms of host recognition of lipid A (a component of lipopolysaccharide), the identification of the genes required for Escherichia coli lipid A biosynthesis, and the role of lipid A acylation when viable bacteria are presented to host cells [12].
  • Certain phosphatidylglycerol-deficient mutants of Escherichia coli accumulate two fatty acylated monosaccharides related to lipid A biosynthesis that have been identified as 2,3-diacylglucosamine 1-phosphate (lipid X) and triacylglucosamine 1-phosphate (lipid Y) (Raetz, C. R. H. (1984) Rev. Infect. Dis. 6, 463-472) [13].
  • We propose that the addition of an R-3-hydroxymyristoyl residue to the 3 position of the GlcNAc moiety of UDP-GlcNAc is the first committed step in lipid A biosynthesis and that UDP-GlcNAc is situated at a biosynthetic branchpoint in E. coli leading either to lipid A or to peptidoglycan [14].

Biological context of msbB


Associations of msbB with chemical compounds


  1. Hierarchical gene expression profiles of HUVEC stimulated by different lipid A structures obtained from Porphyromonas gingivalis and Escherichia coli. Chen, C., Coats, S.R., Bumgarner, R.E., Darveau, R.P. Cell. Microbiol. (2007) [Pubmed]
  2. Antibacterial agents that target lipid A biosynthesis in gram-negative bacteria. Inhibition of diverse UDP-3-O-(r-3-hydroxymyristoyl)-n-acetylglucosamine deacetylases by substrate analogs containing zinc binding motifs. Jackman, J.E., Fierke, C.A., Tumey, L.N., Pirrung, M., Uchiyama, T., Tahir, S.H., Hindsgaul, O., Raetz, C.R. J. Biol. Chem. (2000) [Pubmed]
  3. An Escherichia coli mutant lacking the cold shock-induced palmitoleoyltransferase of lipid A biosynthesis: absence of unsaturated acyl chains and antibiotic hypersensitivity at 12 degrees C. Vorachek-Warren, M.K., Carty, S.M., Lin, S., Cotter, R.J., Raetz, C.R. J. Biol. Chem. (2002) [Pubmed]
  4. Expression cloning and characterization of the C28 acyltransferase of lipid A biosynthesis in Rhizobium leguminosarum. Basu, S.S., Karbarz, M.J., Raetz, C.R. J. Biol. Chem. (2002) [Pubmed]
  5. Modification of lipid A biosynthesis in Neisseria meningitidis lpxL mutants: influence on lipopolysaccharide structure, toxicity, and adjuvant activity. van der Ley, P., Steeghs, L., Hamstra, H.J., ten Hove, J., Zomer, B., van Alphen, L. Infect. Immun. (2001) [Pubmed]
  6. A novel Escherichia coli lipid A mutant that produces an antiinflammatory lipopolysaccharide. Somerville, J.E., Cassiano, L., Bainbridge, B., Cunningham, M.D., Darveau, R.P. J. Clin. Invest. (1996) [Pubmed]
  7. Molecular genetics of membrane phospholipid synthesis. Raetz, C.R. Annu. Rev. Genet. (1986) [Pubmed]
  8. Structure of UDP-N-acetylglucosamine acyltransferase with a bound antibacterial pentadecapeptide. Williams, A.H., Immormino, R.M., Gewirth, D.T., Raetz, C.R. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  9. A Chlamydia trachomatis UDP-N-acetylglucosamine acyltransferase selective for myristoyl-acyl carrier protein. Expression in Escherichia coli and formation of hybrid lipid A species. Sweet, C.R., Lin, S., Cotter, R.J., Raetz, C.R. J. Biol. Chem. (2001) [Pubmed]
  10. High-resolution NMR spectroscopy of lipid A molecules containing 4-amino-4-deoxy-L-arabinose and phosphoethanolamine substituents. Different attachment sites on lipid A molecules from NH4VO3-treated Escherichia coli versus kdsA mutants of Salmonella typhimurium. Zhou, Z., Ribeiro, A.A., Raetz, C.R. J. Biol. Chem. (2000) [Pubmed]
  11. Lipid A biosynthesis in Rhizobium leguminosarum: role of a 2-keto-3-deoxyoctulosonate-activated 4' phosphatase. Price, N.P., Jeyaretnam, B., Carlson, R.W., Kadrmas, J.L., Raetz, C.R., Brozek, K.A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  12. Lipid A diversity and the innate host response to bacterial infection. Darveau, R.P. Curr. Opin. Microbiol. (1998) [Pubmed]
  13. Biosynthesis of lipid A precursors in Escherichia coli. A membrane-bound enzyme that transfers a palmitoyl residue from a glycerophospholipid to lipid X. Brozek, K.A., Bulawa, C.E., Raetz, C.R. J. Biol. Chem. (1987) [Pubmed]
  14. Biosynthesis of lipid A precursors in Escherichia coli. A cytoplasmic acyltransferase that converts UDP-N-acetylglucosamine to UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine. Anderson, M.S., Raetz, C.R. J. Biol. Chem. (1987) [Pubmed]
  15. Biosynthesis of lipid A in Escherichia coli. Acyl carrier protein-dependent incorporation of laurate and myristate. Brozek, K.A., Raetz, C.R. J. Biol. Chem. (1990) [Pubmed]
  16. The envA permeability/cell division gene of Escherichia coli encodes the second enzyme of lipid A biosynthesis. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase. Young, K., Silver, L.L., Bramhill, D., Cameron, P., Eveland, S.S., Raetz, C.R., Hyland, S.A., Anderson, M.S. J. Biol. Chem. (1995) [Pubmed]
  17. An msbB homologue carried in plasmid pO157 encodes an acyltransferase involved in lipid A biosynthesis in Escherichia coli O157:H7. Kim, S.H., Jia, W., Bishop, R.E., Gyles, C. Infect. Immun. (2004) [Pubmed]
  18. The outer membrane of lipid A-deficient Escherichia coli mutant LH530 has reduced levels of OmpF and leaks periplasmic enzymes. Nurminen, M., Hirvas, L., Vaara, M. Microbiology (Reading, Engl.) (1997) [Pubmed]
  19. The active site of Escherichia coli UDP-N-acetylglucosamine acyltransferase. Chemical modification and site-directed mutagenesis. Wyckoff, T.J., Raetz, C.R. J. Biol. Chem. (1999) [Pubmed]
  20. Balanced biosynthesis of major membrane components through regulated degradation of the committed enzyme of lipid A biosynthesis by the AAA protease FtsH (HflB) in Escherichia coli. Ogura, T., Inoue, K., Tatsuta, T., Suzaki, T., Karata, K., Young, K., Su, L.H., Fierke, C.A., Jackman, J.E., Raetz, C.R., Coleman, J., Tomoyasu, T., Matsuzawa, H. Mol. Microbiol. (1999) [Pubmed]
  21. A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin. McClerren, A.L., Endsley, S., Bowman, J.L., Andersen, N.H., Guan, Z., Rudolph, J., Raetz, C.R. Biochemistry (2005) [Pubmed]
  22. Extragenic suppressors of growth defects in msbB Salmonella. Murray, S.R., Bermudes, D., de Felipe, K.S., Low, K.B. J. Bacteriol. (2001) [Pubmed]
  23. An unusual arrangement of pur and lpx genes in the photosynthetic purple sulfur bacterium Allochromatium vinosum. Chen, Y.L., Dincturk, H.B., Knaff, D.B. Mol. Biol. Rep. (1999) [Pubmed]
WikiGenes - Universities