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Chemical Compound Review:

Cerulein

Synonyms: Caerulein, Ceruletida, Ceruletide, Ceruletidum, CCRIS 3063, ...

Wildi, S. et al., Cuzzocrea, S. et al.

Salvatore Cuzzocrea, Giuseppe Malleo, Tiziana Genovese, Emanuela Mazzon, Emanuela Esposito, Carmelo Muià, Maha Abdelrahman, Rosanna Di Paola, Cristoph Thiemermann,

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Disease relevance of Cerulein

Our findings indicate that a functional TGF-beta signalling pathway may be required for caerulein to induce acute pancreatitis and for the CCK receptor to induce acinar cell damage at high ligand concentrations [1].
Inhibition of GSK-3beta reduces the degree of cerulein-induced acute pancreatitis and the associated mortality rate in mice [2].

References

Suppression of transforming growth factor beta signalling aborts caerulein induced pancreatitis and eliminates restricted stimulation at high caerulein concentrations. Wildi, S., Kleeff, J., Mayerle, J., Zimmermann, A., Böttinger, E.P., Wakefield, L., Büchler, M.W., Friess, H., Korc, M. Gut (2007) [Pubmed]
Effects of glycogen synthase kinase-3beta inhibition on the development of cerulein-induced acute pancreatitis in mice. Cuzzocrea, S., Malleo, G., Genovese, T., Mazzon, E., Esposito, E., Muià, C., Abdelrahman, M., Di Paola, R., Thiemermann, C. Crit. Care Med. (2007) [Pubmed]

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