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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

ICILLIN     1-(2-hydroxyphenyl)-4-(3- nitrophenyl)-3,6...

Synonyms: Icilin, Lopac-I-9532, Tocris-1531, CHEMBL258405, SureCN663503, ...
 
 
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High impact information on AG 3-5

  • This action of the five diverse chemicals appears to be subserved by a common pharmacological component, because pretreatment with d-lysergic acid diethylamide (0.03--1.0 mg kg-1, s.c.) attenuated the shaking behavior in a dose-related manner, and cross tolerance was found between RX336-M and TRH, sodium valproate, and AG-3-5 [1].
  • Pharmacological aspects of shaking behavior produced by TRH, AG-3-5, and morphine withdrawal [2].
 

Associations of AG 3-5 with other chemical compounds

  • Thus, rats rendered tolerant to RX 336-M were cross-tolerant to AG-3-5, TRH, and sodium valproate but not to Sgd 8473; in contrast, RX 336-M-induced shaking was only significantly reduced in rats made tolerant to Sgd 8473 [3].

References

  1. Lysergic acid diethylamide antagonizes shaking induced in rats by five chemically different compounds. Cowan, A., Watson, T. Psychopharmacology (Berl.) (1978) [Pubmed]
  2. Pharmacological aspects of shaking behavior produced by TRH, AG-3-5, and morphine withdrawal. Wei, E.T. Fed. Proc. (1981) [Pubmed]
  3. RX 336-M, a new chemical tool in the analysis of the quasi-morphine withdrawal syndrome. Cowan, A. Fed. Proc. (1981) [Pubmed]
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