Gene Review:
TRH - thyrotropin-releasing hormone
Homo sapiens
Synonyms:
Pro-TRH, Pro-thyrotropin-releasing hormone, Prothyroliberin, TRF
- Thyrotropin-releasing hormone (TRH) receptor number determines the size of the TRH-responsive phosphoinositide pool. Demonstration using controlled expression of TRH receptors by adenovirus mediated gene transfer. Gershengorn, M.C., Heinflink, M., Nussenzveig, D.R., Hinkle, P.M., Falck-Pedersen, E. J. Biol. Chem. (1994)
- Increase in plasma growth hormone levels following thyrotropin-releasing hormone injection in children with primary hypothyroidism. Collu, R., Leboeuf, G., Letarte, J., Ducharme, J.R. J. Clin. Endocrinol. Metab. (1977)
- Effects of hypophysiotropic factors on growth hormone and prolactin secretion from somatotroph adenomas in culture. Ishibashi, M., Yamaji, T. J. Clin. Endocrinol. Metab. (1985)
- Growth hormone and prolactin responses to thyrotropin-releasing hormone in patients with severe liver disease. Panerai, A.E., Salerno, F., Manneschi, M., Cocchi, D., Müller, E.E. J. Clin. Endocrinol. Metab. (1977)
- Prolactin in patients with major depressive disorder and in healthy subjects. III. Investigation of basal and post-TRH prolactin during different forms of acute and chronic psychological stress. Baumgartner, A., Gräf, K.J., Kürten, I. Biol. Psychiatry (1988)
- Behavioral and endocrine interactions between thyrotropin-releasing hormone and ethanol in normal human subjects. Garbutt, J.C., Hicks, R.E., Clayton, C.J., Andrews, R.T., Mason, G.A. Alcohol. Clin. Exp. Res. (1991)
- Orexis, anorexia, and thyrotropin-releasing hormone. Karydis, I., Tolis, G. Thyroid (1998)
- Effect of TRH on TSH and prolactin levels in affective disorders. Kjellman, B.F., Ljunggren, J.G., Beck-Friis, J., Wetterberg, L. Psychiatry research. (1985)
- Stimulation and inhibition of food intake in sheep by centrally-administered hypothalamic releasing factors. Ruckebusch, Y., Malbert, C.H. Life Sci. (1986)
- Antenatal thyrotropin-releasing hormone to prevent lung disease in preterm infants. North American Thyrotropin-Releasing Hormone Study Group. Ballard, R.A., Ballard, P.L., Cnaan, A., Pinto-Martin, J., Davis, D.J., Padbury, J.F., Phibbs, R.H., Parer, J.T., Hart, M.C., Mannino, F.L., Sawai, S.K. N. Engl. J. Med. (1998)
- Recognition of gonadotroph adenomas in women. Daneshdoost, L., Gennarelli, T.A., Bashey, H.M., Savino, P.J., Sergott, R.C., Bosley, T.M., Snyder, P.J. N. Engl. J. Med. (1991)
- Maturation of the secretion of thyroid hormone and thyroid-stimulating hormone in the fetus. Thorpe-Beeston, J.G., Nicolaides, K.H., Felton, C.V., Butler, J., McGregor, A.M. N. Engl. J. Med. (1991)
- Effects of disodium EDTA and calcium infusion on prolactin and thyrotropin responses to thyrotropin-releasing hormone in healthy man. Dudczak, R., Waldhäusl, W.K., Bratusch-Marrain, P. J. Clin. Endocrinol. Metab. (1983)
- Prolactin and TSH response to TRH and metoclopramide before and after l-thyroxine therapy in subclinical hypothyroidism. Lombardi, G., Iodice, M., Miletto, P., Merola, B., Panza, N., Annunziato, L. Neuroendocrinology (1986)
- Prolactin response to thyrotropin-releasing hormone (TRH) in patients with hypothalamic-pituitary disease. Barbieri, R.L., Cooper, D.S., Daniels, G.H., Nathan, D., Klibanski, A., Ridgway, E.C. Fertil. Steril. (1985)
- Prolactin secretion after surgery or bromocriptine treatment of prolactinoma. De Leo, V., Petraglia, F., Sardelli, S., Danero, S., Genazzani, A.R., D'Antona, N. Obstetrics and gynecology. (1987)
- Reproductive functions in obese women. Kumar, A., Mittal, S., Buckshee, K., Farooq, A. Progress in food & nutrition science. (1993)
- A constitutively active mutant thyrotropin-releasing hormone receptor is chronically down-regulated in pituitary cells: evidence using chlordiazepoxide as a negative antagonist. Heinflink, M., Nussenzveig, D.R., Grimberg, H., Lupu-Meiri, M., Oron, Y., Gershengorn, M.C. Mol. Endocrinol. (1995)
- A model of inverse agonist action at thyrotropin-releasing hormone receptor type 1: role of a conserved tryptophan in helix 6. Lu, X., Huang, W., Worthington, S., Drabik, P., Osman, R., Gershengorn, M.C. Mol. Pharmacol. (2004)
- Effect of cell type on the subcellular localization of the thyrotropin-releasing hormone receptor. Yu, R., Hinkle, P.M. Mol. Pharmacol. (1997)
- The molecular mechanism of EGF receptor activation in pancreatic beta-cells by thyrotropin-releasing hormone. Luo, L., Yano, N., Luo, J.Z. Am. J. Physiol. Endocrinol. Metab. (2006)
- The effect of thyrotropin-releasing hormone stimulation on serum levels of gonadotropins in women during the follicular and luteal phases of the menstrual cycle. Colon, J.M., Lessing, J.B., Yavetz, C., Peyser, M.R., Ganguly, M., Weiss, G. Fertil. Steril. (1988)
- Visualization of the thyrotropin-releasing hormone receptor and its ligand during endocytosis and recycling. Ashworth, R., Yu, R., Nelson, E.J., Dermer, S., Gershengorn, M.C., Hinkle, P.M. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Prolactin in patients with major depressive disorder and in healthy subjects. I. Cross-sectional study of basal and post-TRH and postdexamethasone prolactin levels. Baumgartner, A., Gräf, K.J., Kürten, I. Biol. Psychiatry (1988)
- Altered ligand dissociation rates in thyrotropin-releasing hormone receptors mutated in glutamine 105 of transmembrane helix III. del Camino, D., Barros, F., Pardo, L.A., de la Peña, P. Biochemistry (1997)
- Desensitization of thyrotropin-releasing hormone receptor-mediated responses involves multiple steps. Yu, R., Hinkle, P.M. J. Biol. Chem. (1997)
- Thyrotropin-releasing hormone-induced subcellular redistribution and down-regulation of G11alpha: analysis of agonist regulation of coexpressed G11alpha species variants. Svoboda, P., Kim, G.D., Grassie, M.A., Eidne, K.A., Milligan, G. Mol. Pharmacol. (1996)
- Prolactin molecular heterogeneity. Response to thyrotropin-releasing hormone stimulation of concanavalin A-bound and -unbound immunoassayable prolactin during human pregnancy. Shoupe, D., Montz, F.J., Kletzky, O.A., diZerega, G.S. Am. J. Obstet. Gynecol. (1983)
- The interaction of GHRH with TRH in acromegaly: a controlled study. Looij, B.J., Roelfsema, F., Frölich, M., Nieuwenhuijzen Kruseman, A.C. Acta Endocrinol. (1991)
- Pit-1/GHF-1 binds to TRH-sensitive regions of the rat thyrotropin beta gene. Mason, M.E., Friend, K.E., Copper, J., Shupnik, M.A. Biochemistry (1993)
- Thyrotropin-releasing hormone and its receptors - A hypothesis for binding and receptor activation. Engel, S., Gershengorn, M.C. Pharmacol. Ther. (2007)
- Epidermal growth factor decreases the concentration of thyrotropin-releasing hormone (TRH) receptors and TRH responses in pituitary GH4C1 cells. Hinkle, P.M., Shanshala, E.D., Yan, Z.F. Endocrinology (1991)
- Inhibitory influence of thyrotropin releasing hormone administration on growth hormone response to low doses of growth hormone-releasing hormone in normal man. Zanoboni, A., Gibillini, M., Cucchi, M.R., Zanoboni Muciaccia, W., Zanussi, C. J. Endocrinol. Invest. (1988)
- Corticotropin-releasing hormone inhibition of paradoxical growth hormone response to thyrotropin-releasing hormone in insulin-dependent diabetics. Barbarino, A., Corsello, S.M., Tofani, A., Sciuto, R., Della Casa, S., Rota, C.A., Colasanti, S., Barini, A. Metab. Clin. Exp. (1992)
- Neuropeptide Y inhibits spontaneous alpha-melanocyte-stimulating hormone (alpha-MSH) release via a Y(5) receptor and suppresses thyrotropin-releasing hormone-induced alpha-MSH secretion via a Y(1) receptor in frog melanotrope cells. Galas, L., Tonon, M.C., Beaujean, D., Fredriksson, R., Larhammar, D., Lihrmann, I., Jegou, S., Fournier, A., Chartrel, N., Vaudry, H. Endocrinology (2002)
- Alpha-melanocyte stimulating hormone release in response to thyrotropin releasing hormone in healthy horses, horses with pituitary pars intermedia dysfunction and equine pars intermedia explants. McFarlane, D., Beech, J., Cribb, A. Domest. Anim. Endocrinol. (2006)
- Thyrotropin-releasing hormone inhibits pancreatic enzyme secretion in humans. Gullo, L., Labò, G. Gastroenterology (1981)
- Contingent tolerance to the anticonvulsant effects of carbamazepine: relationship to loss of endogenous adaptive mechanisms. Weiss, S.R., Clark, M., Rosen, J.B., Smith, M.A., Post, R.M. Brain Res. Brain Res. Rev. (1995)
- Neuropeptides and human sleep. Steiger, A., Holsboer, F. Sleep. (1997)
- The detection of thyrotropin-releasing hormone (TRH) and TRH receptor gene expression in Siberian hamster testes. Rao, J.N., Debeljuk, L., Bartke, A., Gao, Y.P., Wilber, J.F., Feng, P. Peptides (1997)
- Prolactin and TSH responses to TRH and to haloperidol in schizophrenic patients before and after treatment. Markianos, M., Hatzimanolis, J., Stefanis, C. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (1994)
- Thyrotropin-releasing hormone enhances event-related brain potentials and growth hormone release in man. Strollo, F., Amabile, G., Fattapposta, F., Strollo, G., More, M., Riondino, G. Neurosci. Lett. (1988)