Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AICOR 5-amino-1-[(2R,3R,4S,5R)-3,4- dihydroxy-5...

Synonyms: CAIR, Carboxy-air, SureCN4359558, CHEBI:28413, HMDB06273, ...

Firestine, S.M. et al., Firestine, S.M. et al.

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Disease relevance of Carboxy-air

In Escherichia coli, two enzymes PurK and PurE are required for the transformation of AIR to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [1].

High impact information on Carboxy-air

Distinctive features of the PurE active site were probed using 4-nitro-5-aminoimidazole ribonucleotide (NAIR), an analog of the product 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [2].

References

Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms. Firestine, S.M., Poon, S.W., Mueller, E.J., Stubbe, J., Davisson, V.J. Biochemistry (1994) [Pubmed]
Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis. Firestine, S.M., Misialek, S., Toffaletti, D.L., Klem, T.J., Perfect, J.R., Davisson, V.J. Arch. Biochem. Biophys. (1998) [Pubmed]

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