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Chemical Compound Review

preQ1     4-amino-9-(aminomethyl)- 3,5,7...

Synonyms: SureCN166747, AG-K-81140, CHEBI:45126, HMDB11690, CTK7E3986, ...
 
 
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Disease relevance of preQ1

  • In E. coli this modification occurs via a two-step reaction: (1) TGT-catalyzed base exchange of guanosine-34 with preQ1 (7-aminomethyl-7-deazaguanine) and (2) addition of a cyclopentenediol moiety to the preQ1-34 tRNA [1].
 

High impact information on preQ1

References

  1. tRNA-guanine transglycosylase from Escherichia coli. Overexpression, purification and quaternary structure. Garcia, G.A., Koch, K.A., Chong, S. J. Mol. Biol. (1993) [Pubmed]
  2. Structure and organization of Escherichia coli genes involved in biosynthesis of the deazaguanine derivative queuine, a nutrient factor for eukaryotes. Reuter, K., Slany, R., Ullrich, F., Kersten, H. J. Bacteriol. (1991) [Pubmed]
  3. Crystallization and preliminary X-ray characterization of the nitrile reductase QueF: a queuosine-biosynthesis enzyme. Swairjo, M.A., Reddy, R.R., Lee, B., Van Lanen, S.G., Brown, S., de Crécy-Lagard, V., Iwata-Reuyl, D., Schimmel, P. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2005) [Pubmed]
  4. Substrate and inhibitor specificity of tRNA-guanine ribosyltransferase. Farkas, W.R., Jacobson, K.B., Katze, J.R. Biochim. Biophys. Acta (1984) [Pubmed]
 
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