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Chemical Compound Review:

Phe-pA [(2S)-2-amino-3-phenyl- propanoyl]oxy-[[(2R...

Synonyms: SureCN4945718, AC1L4WWE, AR-1G9210, AC1Q68Q9, 35874-27-2, ...

Lacey, J.C. et al., Moor, N. et al., Reshetnikova, L. et al., Rapaport, E. et al., McMasters, D.R. et al., et al.

Fu, Han, Zhao, Tu, Xu, Lu, Wang, Xiao,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Phenylalanyl adenylate

The crystal structure of the ternary complex of (alphabeta)(2) heterotetrameric phenylalanyl-tRNA synthetase (PheRS) from Thermus thermophilus with cognate tRNA(Phe) and a nonhydrolyzable phenylalanyl-adenylate analogue (PheOH-AMP) has been determined at 3.1 A resolution [1].

High impact information on Phenylalanyl adenylate

The ability of PRS to undergo this covalent modification directly correlates with its ability to catalyze the synthesis of diadenosine 5',5"'-P1,P4-tetraphosphate from enzyme-bound phenylalanyl adenylate [2].
The complex structures suggest that the PheRS beta-subunit may affect the first step of the reaction (formation of phenylalanyl-adenylate) through the metal-mediated conserved alpha/beta-subunit interface [3].
Using the crystal structure of PheRS from Thermusthermophilus, we have modeled its interactions with OA as well as with phenylalanyl adenylate (FAMP), the high-affinity intermediate substrate of PheRS [4].
Synthesis and hydrolysis of a phenylalanyl adenylate pentacoordinated phosphorane [5].

Associations of Phenylalanyl adenylate with other chemical compounds

We have used a novel spectrophotometric method to study the hydrolysis of N-acetylphenylalanyl adenylate anhydride (AcPhe-AMP) and phenylalanyl-adenylate anhydride (Phe-AMP) at low concentrations (10(-5) M), 25 degrees C, constant buffer concentration (0.05 M), and as a function of pH [6].

References

The crystal structure of the ternary complex of phenylalanyl-tRNA synthetase with tRNAPhe and a phenylalanyl-adenylate analogue reveals a conformational switch of the CCA end. Moor, N., Kotik-Kogan, O., Tworowski, D., Sukhanova, M., Safro, M. Biochemistry (2006) [Pubmed]
Covalent modification of phenylalanyl-tRNA synthetase with phenylalanine during the amino acid activation reaction catalyzed by the enzyme. Rapaport, E., Yogeeswaran, G., Zamecnik, P.C., Remy, P. J. Biol. Chem. (1985) [Pubmed]
Crystal structures of phenylalanyl-tRNA synthetase complexed with phenylalanine and a phenylalanyl-adenylate analogue. Reshetnikova, L., Moor, N., Lavrik, O., Vassylyev, D.G. J. Mol. Biol. (1999) [Pubmed]
Ochratoxin binding to phenylalanyl-tRNA synthetase: computational approach to the mechanism of ochratoxicosis and its antagonism. McMasters, D.R., Vedani, A. J. Med. Chem. (1999) [Pubmed]
Synthesis and hydrolysis of a phenylalanyl adenylate pentacoordinated phosphorane. Fu, H., Han, B., Zhao, Y.F., Tu, G.Z., Xu, L., Lu, Q., Wang, J.Z., Xiao, H.Z. Bioorg. Chem. (2003) [Pubmed]
Hydrolytic properties of phenylalanyl- and N-acetylphenylalanyl adenylate anhydrides. Lacey, J.C., Senaratne, N., Mullins, D.W. Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life. (1984) [Pubmed]

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