Chemical Compound Review:
Atpenin B 3-[(2S,4R)-2,4- dimethylhexanoyl]-2- hydroxy...
Synonyms:
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High impact information on Atpenin B
- The incorporation of [14C]leucine and [3H]thymidine into Raji cells was inhibited by atpenin B with IC50 values of 0.10 and 0.12 microM, respectively [1].
- Studies on the site of atpenin B action demonstrated that atpenin B decreases the cellular adenosine 5'-triphosphate (ATP) level in Raji cells with IC50 value of 0.020 microM, suggesting the inhibition of ATP-generating system by atpenin B [1].
References
- Mechanism of action of atpenin B on Raji cells. Oshino, K., Kumagai, H., Tomoda, H., Omura, S. J. Antibiot. (1990) [Pubmed]
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