Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

SureCN665488 1,4,7,8- tetrazabicyclo[4.3.0]nona- 2,4,6,8...

Synonyms: AG-K-66936, NSC-68466, KST-1B3177, AC1Q4YGF, NSC68466, ...

Kelley, J.L. et al., Bradbury, R.H. et al.

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Disease relevance of NSC68466

The 1,2,4-triazolo[4,3-a]pyrazine ring system serves as a bioisostere of the purine ring for anticonvulsant activity; however, these agents exhibit less propensity to cause emesis [1].

High impact information on NSC68466

1,2,4-Triazolo[4,3-a]pyrazine derivatives with human renin inhibitory activity. 3.1 Synthesis and biological properties of aminodeoxystatine and difluorostatone derivatives [2].

References

8-Amino-3-benzyl-1,2,4-triazolo[4,3-a]pyrazines. Synthesis and anticonvulsant activity. Kelley, J.L., Linn, J.A., Bankston, D.D., Burchall, C.J., Soroko, F.E., Cooper, B.R. J. Med. Chem. (1995) [Pubmed]
1,2,4-Triazolo[4,3-a]pyrazine derivatives with human renin inhibitory activity. 3.1 Synthesis and biological properties of aminodeoxystatine and difluorostatone derivatives. Bradbury, R.H., Rivett, J.E. J. Med. Chem. (1991) [Pubmed]

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