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Chemical Compound Review: 

MSC-127     3-(5-chloropyridin-2-yl)-1- [(1R,2S)-2-(2,6...

Synonyms: AC1MHDJ3
 
 
 
 
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Disease relevance of MSC-127

 

High impact information on MSC-127

  • The prototype compound trovirdine (LY 300046 HCl) and one analogue, MSC-127, have been studied with respect to inhibition of wild-type HIV-1 RT and RT with various mutations known to give rise to resistance to other non-nucleoside RT inhibitors, namely Leu100-->Ile (Ile100), Glu138-->Arg (Arg138), Tyr181-->Cys (Cys181) and Tyr188-->His (His188) [1].

References

  1. Inhibition of human immunodeficiency virus type 1 wild-type and mutant reverse transcriptases by the phenyl ethyl thiazolyl thiourea derivatives trovirdine and MSC-127. Zhang, H., Vrang, L., Bäckbro, K., Lind, P., Sahlberg, C., Unge, T., Oberg, B. Antiviral Res. (1995) [Pubmed]
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