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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AC1MHP4H     2-(2-methoxy-4-prop-2-enyl- phenoxy)-1-[4...

Synonyms: LS-110388, TK86800000, NIOSH/TK8680000
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Gene context of AP 1

  • The expression of dominant negative JNK1 inhibited c-Jun phosphorylation, AP-1 activation, and hepatic injury following I/R in JunD-/- mice but, paradoxically, led to an enhancement of AP-1 activation and liver injury in JunD+/- littermates [1].


  1. JunD protects the liver from ischemia/reperfusion injury by dampening AP-1 transcriptional activation. Marden, J.J., Zhang, Y., Oakley, F.D., Zhou, W., Luo, M., Jia, H.P., McCray, P.B., Yaniv, M., Weitzman, J.B., Engelhardt, J.F. J. Biol. Chem. (2008) [Pubmed]
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