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Chemical Compound Review:

beta-Proline pyrrolidine-3-carboxylic acid

Synonyms: AC1MHXYA, PubChem10439, SureCN444559, AC-710, AG-G-11608, ...

Kim, Y.J. et al., Cardillo, G. et al., Cardillo, G. et al.

Cardillo, Gentilucci, Tolomelli, Calienni, Qasem, Spampinato,

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High impact information on beta-Proline

Endomorphin-1 analogues containing beta-proline are mu-opioid receptor agonists and display enhanced enzymatic hydrolysis resistance [1].
The beta-proline decamer, however, failed to bind to profilin, whereas the corresponding alpha-L-proline decamer bound tightly to this protein [2].
Stability against enzymatic hydrolysis of endomorphin-1 analogues containing beta-proline [3].

References

Endomorphin-1 analogues containing beta-proline are mu-opioid receptor agonists and display enhanced enzymatic hydrolysis resistance. Cardillo, G., Gentilucci, L., Qasem, A.R., Sgarzi, F., Spampinato, S. J. Med. Chem. (2002) [Pubmed]
Synthesis of (3R)-carboxy pyrrolidine (a beta-proline analogue) and its oligomer. Kim, Y.J., Kaiser, D.A., Pollard, T.D., Ichikawa, Y. Bioorg. Med. Chem. Lett. (2000) [Pubmed]
Stability against enzymatic hydrolysis of endomorphin-1 analogues containing beta-proline. Cardillo, G., Gentilucci, L., Tolomelli, A., Calienni, M., Qasem, A.R., Spampinato, S. Org. Biomol. Chem. (2003) [Pubmed]

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