The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Endomorphin-1     (2S)-N-[(1S)-1-[[(1S)-1- aminocarbonyl-2...

Synonyms: Endomorphin 1, AC1NSJYK, CHEMBL316446, HMDB05773, CHEBI:239449, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Endomorphin 1


Psychiatry related information on Endomorphin 1

  • These results suggest that endomorphin-1 improves the disturbance of short-term memory resulting from cholinergic dysfunction through the mediation of mu1-opioid receptors [5].
  • In contrast, physostigmine (0.025 and 0.05 mg/kg, i.p.) significantly reversed the endomorphin-1 (10 microg)- and endomorphin-2 (10 microg)-induced disturbance of passive avoidance learning, whereas physostigmine (0.025 and 0.05 mg/kg, i.p.) alone did not influence such learning [6].
  • The distribution of EM1 suggests a potential endogenous role for this peptide in major processes modulated by opiates, including affective states and social behavior [7].

High impact information on Endomorphin 1


Chemical compound and disease context of Endomorphin 1

  • Infusions of selective MOR agonists, H-Tyr-d-Ala-Gly-N-Met-Phe-glycinol-enkephalin (DAMGO) or endomorphin-1, into the medial preoptic nucleus attenuated lordosis, and their effects were blocked with the MOR antagonist H-d-Phe-Cys-Tyr-d-Trp-Orn-Thr-Pen-Thr-NH(2) (CTOP) [10].

Biological context of Endomorphin 1


Anatomical context of Endomorphin 1


Associations of Endomorphin 1 with other chemical compounds


Gene context of Endomorphin 1


Analytical, diagnostic and therapeutic context of Endomorphin 1


  1. Antinociceptive effect of continuous intrathecal administration of endomorphin-1. Csullog, E., Joo, G., Toth, G., Dobos, I., Benedek, G., Horvath, G. Pain (2001) [Pubmed]
  2. Endomorphin-1 potentiates HIV-1 expression in human brain cell cultures: implication of an atypical mu-opioid receptor. Peterson, P.K., Gekker, G., Hu, S., Lokensgard, J., Portoghese, P.S., Chao, C.C. Neuropharmacology (1999) [Pubmed]
  3. Activation of mu-opioid receptors inhibits lordosis behavior in estrogen and progesterone-primed female rats. Acosta-Martinez, M., Etgen, A.M. Hormones and behavior. (2002) [Pubmed]
  4. Endomorphins decrease heart rate and blood pressure possibly by activating vagal afferents in anesthetized rats. Kwok, E.H., Dun, N.J. Brain Res. (1998) [Pubmed]
  5. Endomorphin-1 improves scopolamine-induced impairment of short-term memory via mu1-opioid receptor in mice. Ukai, M., Katoh, T., Mamiya, T. Neuroreport (2001) [Pubmed]
  6. Involvement of mu(1)-opioid receptors and cholinergic neurotransmission in the endomorphins-induced impairment of passive avoidance learning in mice. Ukai, M., Lin, H.P. Behav. Brain Res. (2002) [Pubmed]
  7. Endomorphin1-like immunoreactivity in the limbic system of Syrian hamsters (Mesocricetus auratus). Whitten, R.D., Martin-Schild, S., Zadina, J.E., Albers, H.E. Brain Res. Bull. (2001) [Pubmed]
  8. Chronic arthritis down-regulates peripheral mu-opioid receptor expression with concomitant loss of endomorphin 1 antinociception. Li, Z., Proud, D., Zhang, C., Wiehler, S., McDougall, J.J. Arthritis Rheum. (2005) [Pubmed]
  9. The alpha9/alpha10-containing nicotinic ACh receptor is directly modulated by opioid peptides, endomorphin-1, and dynorphin B, proposed efferent cotransmitters in the inner ear. Lioudyno, M.I., Verbitsky, M., Glowatzki, E., Holt, J.C., Boulter, J., Zadina, J.E., Elgoyhen, A.B., Guth, P.S. Mol. Cell. Neurosci. (2002) [Pubmed]
  10. Progesterone blockade of estrogen activation of mu-opioid receptors regulates reproductive behavior. Sinchak, K., Micevych, P.E. J. Neurosci. (2001) [Pubmed]
  11. Endomorphins inhibit high-threshold Ca2+ channel currents in rodent NG108-15 cells overexpressing mu-opioid receptors. Higashida, H., Hoshi, N., Knijnik, R., Zadina, J.E., Kastin, A.J. J. Physiol. (Lond.) (1998) [Pubmed]
  12. Cardiovascular responses to microinjection of nociceptin and endomorphin-1 into the nucleus tractus solitarii in conscious rats. Mao, L., Wang, J.Q. Neuroscience (2005) [Pubmed]
  13. Modulation of synaptic transmission in the rat nucleus of the solitary tract by endomorphin-1. Glatzer, N.R., Smith, B.N. J. Neurophysiol. (2005) [Pubmed]
  14. Endomorphin-like immunoreactivity in the rat dorsal horn and inhibition of substantia gelatinosa neurons in vitro. Wu, S.Y., Dun, S.L., Wright, M.T., Chang, J.K., Dun, N.J. Neuroscience (1999) [Pubmed]
  15. Immunohistochemical localization of endomorphin-1 and endomorphin-2 in immune cells and spinal cord in a model of inflammatory pain. Mousa, S.A., Machelska, H., Schäfer, M., Stein, C. J. Neuroimmunol. (2002) [Pubmed]
  16. Endomorphin-stimulated [35S]GTPgammaS binding in rat brain: evidence for partial agonist activity at mu-opioid receptors. Sim, L.J., Liu, Q., Childers, S.R., Selley, D.E. J. Neurochem. (1998) [Pubmed]
  17. Stereochemical requirements for receptor recognition of the mu-opioid peptide endomorphin-1. Paterlini, M.G., Avitabile, F., Ostrowski, B.G., Ferguson, D.M., Portoghese, P.S. Biophys. J. (2000) [Pubmed]
  18. Endomorphin-1 and -2 immunoreactive cells in the hypothalamus are labeled by fluoro-gold injections to the ventral tegmental area. Greenwell, T.N., Zangen, A., Martin-Schild, S., Wise, R.A., Zadina, J.E. J. Comp. Neurol. (2002) [Pubmed]
  19. Coupling efficacy and selectivity of the human mu-opioid receptor expressed as receptor-Galpha fusion proteins in Escherichia coli. Stanasila, L., Lim, W.K., Neubig, R.R., Pattus, F. J. Neurochem. (2000) [Pubmed]
  20. Effects of the endogenous opioid peptide, endomorphin 1, on supraoptic nucleus oxytocin and vasopressin neurones in vivo and in vitro. Doi, N., Brown, C.H., Cohen, H.D., Leng, G., Russell, J.A. Br. J. Pharmacol. (2001) [Pubmed]
  21. Functional characterization of opioid receptor ligands by aequorin luminescence-based calcium assay. Fichna, J., Gach, K., Piestrzeniewicz, M., Burgeon, E., Poels, J., Broeck, J.V., Janecka, A. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  22. Inhibition by endomorphin-1 and endomorphin-2 of excitatory transmission in adult rat substantia gelatinosa neurons. Fujita, T., Kumamoto, E. Neuroscience (2006) [Pubmed]
  23. Endomorphin 1 activates nitric oxide synthase 2 activity and downregulates nitric oxide synthase 2 mRNA expression. Sarić, A., Balog, T., Sobocanec, S., Marotti, T. Neuroscience (2007) [Pubmed]
  24. Organization of endogenous opioids in the rostral agranular insular cortex of the rat. Evans, J.M., Bey, V., Burkey, A.R., Commons, K.G. J. Comp. Neurol. (2007) [Pubmed]
  25. Differential alteration of functions of rat peritoneal macrophages responsive to endogenous opioid peptide endomorphin-1. Inui, Y., Azuma, Y., Ohura, K. Int. Immunopharmacol. (2002) [Pubmed]
  26. Regulation of eNOS expression in HCAEC cell line treated with opioids and proinflammatory cytokines. Seidel, M., Billert, H., Kurpisz, M. Kardiologia polska. (2006) [Pubmed]
  27. The fibroblast growth factor receptor is at the site of convergence between mu-opioid receptor and growth factor signaling pathways in rat C6 glioma cells. Belcheva, M.M., Haas, P.D., Tan, Y., Heaton, V.M., Coscia, C.J. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  28. Endomorphin-1 and endomorphin-2, endogenous ligands for the mu-opioid receptor, inhibit electrical activity of rat rostral ventrolateral medulla neurons in vitro. Chu, X.P., Xu, N.S., Li, P., Wang, J.Q. Neuroscience (1999) [Pubmed]
  29. Differential distribution of endomorphin 1- and endomorphin 2-like immunoreactivities in the CNS of the rodent. Martin-Schild, S., Gerall, A.A., Kastin, A.J., Zadina, J.E. J. Comp. Neurol. (1999) [Pubmed]
  30. The reciprocal connections of endomorphin 1- and endomorphin 2-containing neurons between the hypothalamus and nucleus tractus solitarii in the rat. Hui, R., Chen, T., Li, Y.Q. Neuroscience (2006) [Pubmed]
WikiGenes - Universities