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Chemical Compound Review:

Robalzotan (3R)-3-(dicyclobutylamino)-8- fluoro...

Synonyms: AC1MHOZC, SureCN115079, CHEMBL1628569, DNC001228, LS-182403, ...

Farde, L. et al., Mucke, H.A.

Mucke,

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High impact information on Robalzotan

AstraZeneca (formerly Astra) is developing robalzotan, a 5-HT1A antagonist, for the potential treatment of depression and anxiety [1].

Analytical, diagnostic and therapeutic context of Robalzotan

The aim of this positron emission tomography study was to determine 5-HT(1A) receptor occupancy in the cynomolgus monkey brain in vivo after IV injection of robalzotan [2].

References

Robalzotan AstraZeneca. Mucke, H.A. Current opinion in investigational drugs (London, England : 2000) (2000) [Pubmed]
PET-Determination of robalzotan (NAD-299) induced 5-HT(1A) receptor occupancy in the monkey brain. Farde, L., Andrée, B., Ginovart, N., Halldin, C., Thorberg, S. Neuropsychopharmacology (2000) [Pubmed]

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