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MeSH Review

Macaca fascicularis

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Disease relevance of Macaca fascicularis


Psychiatry related information on Macaca fascicularis


High impact information on Macaca fascicularis

  • Endotoxin-free thymosin fraction 5 elevated corticotropin, beta-endorphin, and cortisol in a dose- and time-dependent fashion when administered intravenously to prepubertal cynomolgus monkeys [8].
  • We report here the comparison of the adhesin knockout mutant (DS17-8) and the class-switch mutant (DS17-1) with the wild-type (DS17) for in vivo colonization of the gut, vagina, and bladder of cynomolgus monkeys [9].
  • We studied proliferation and interleukin 2 production by B6 mouse spleen cells in response to stimulation by irradiated cynomolgus monkey spleen cells and compared the results with responses against whole MHC-disparate allogeneic controls (BALB/c) [10].
  • A hydroxyl radical-like species oxidizes cynomolgus monkey artery wall proteins in early diabetic vascular disease [4].
  • The remarkable similarities between the simian and B19 parvoviruses suggest that experimentally infected cynomolgus monkeys may serve as a useful animal model of human B19 infection [11].

Chemical compound and disease context of Macaca fascicularis


Biological context of Macaca fascicularis


Anatomical context of Macaca fascicularis


Associations of Macaca fascicularis with chemical compounds


Gene context of Macaca fascicularis


Analytical, diagnostic and therapeutic context of Macaca fascicularis


  1. A novel testis-stimulating factor in familial male precocious puberty. Manasco, P.K., Girton, M.E., Diggs, R.L., Doppman, J.L., Feuillan, P.P., Barnes, K.M., Cutler, G.B., Loriaux, D.L., Albertson, B.D. N. Engl. J. Med. (1991) [Pubmed]
  2. Augmentation of fetal-hemoglobin production in anemic monkeys by hydroxyurea. Letvin, N.L., Linch, D.C., Beardsley, G.P., McIntyre, K.W., Nathan, D.G. N. Engl. J. Med. (1984) [Pubmed]
  3. A monkey model for Epstein Barr virus-associated lymphomagenesis in human acquired immunodeficiency syndrome. Feichtinger, H., Li, S.L., Kaaya, E., Putkonen, P., Grünewald, K., Weyrer, K., Böttiger, D., Ernberg, I., Linde, A., Biberfeld, G. J. Exp. Med. (1992) [Pubmed]
  4. A hydroxyl radical-like species oxidizes cynomolgus monkey artery wall proteins in early diabetic vascular disease. Pennathur, S., Wagner, J.D., Leeuwenburgh, C., Litwak, K.N., Heinecke, J.W. J. Clin. Invest. (2001) [Pubmed]
  5. Estrogen and progesterone replacement therapy reduces low density lipoprotein accumulation in the coronary arteries of surgically postmenopausal cynomolgus monkeys. Wagner, J.D., Clarkson, T.B., St Clair, R.W., Schwenke, D.C., Shively, C.A., Adams, M.R. J. Clin. Invest. (1991) [Pubmed]
  6. Induction and maintenance of ethanol self-administration in cynomolgus monkeys (Macaca fascicularis): long-term characterization of sex and individual differences. Vivian, J.A., Green, H.L., Young, J.E., Majerksy, L.S., Thomas, B.W., Shively, C.A., Tobin, J.R., Nader, M.A., Grant, K.A. Alcohol. Clin. Exp. Res. (2001) [Pubmed]
  7. Predictors of social status in cynomolgus monkeys (Macaca fascicularis) after group formation. Morgan, D., Grant, K.A., Prioleau, O.A., Nader, S.H., Kaplan, J.R., Nader, M.A. Am. J. Primatol. (2000) [Pubmed]
  8. The thymus-adrenal connection: thymosin has corticotropin-releasing activity in primates. Healy, D.L., Hodgen, G.D., Schulte, H.M., Chrousos, G.P., Loriaux, D.L., Hall, N.R., Goldstein, A.L. Science (1983) [Pubmed]
  9. The PapG-adhesin at the tip of P-fimbriae provides Escherichia coli with a competitive edge in experimental bladder infections of cynomolgus monkeys. Winberg, J., Möllby, R., Bergström, J., Karlsson, K.A., Leonardsson, I., Milh, M.A., Teneberg, S., Haslam, D., Marklund, B.I., Normark, S. J. Exp. Med. (1995) [Pubmed]
  10. Xenogeneic proliferation and lymphokine production are dependent on CD4+ helper T cells and self antigen-presenting cells in the mouse. Moses, R.D., Pierson, R.N., Winn, H.J., Auchincloss, H. J. Exp. Med. (1990) [Pubmed]
  11. Identification of a novel simian parvovirus in cynomolgus monkeys with severe anemia. A paradigm of human B19 parvovirus infection. O'Sullivan, M.G., Anderson, D.C., Fikes, J.D., Bain, F.T., Carlson, C.S., Green, S.W., Young, N.S., Brown, K.E. J. Clin. Invest. (1994) [Pubmed]
  12. Preclinical toxicology of zidovudine. An overview. Ayers, K.M. Am. J. Med. (1988) [Pubmed]
  13. Behaviorally elicited heart rate reactivity and atherosclerosis in ovariectomized cynomolgus monkeys (Macaca fascicularis). Manuck, S.B., Adams, M.R., McCaffery, J.M., Kaplan, J.R. Arterioscler. Thromb. Vasc. Biol. (1997) [Pubmed]
  14. Esterified estrogens with and without methyltestosterone decrease arterial LDL metabolism in cynomolgus monkeys. Wagner, J.D., Zhang, L., Williams, J.K., Register, T.C., Ackerman, D.M., Wiita, B., Clarkson, T.B., Adams, M.R. Arterioscler. Thromb. Vasc. Biol. (1996) [Pubmed]
  15. Antiparkinsonian effect of a new selective adenosine A2A receptor antagonist in MPTP-treated monkeys. Grondin, R., Bédard, P.J., Hadj Tahar, A., Grégoire, L., Mori, A., Kase, H. Neurology (1999) [Pubmed]
  16. The opioid agonist morphine decreases the dyskinetic response to dopaminergic agents in parkinsonian monkeys. Samadi, P., Grégoire, L., Bédard, P.J. Neurobiol. Dis. (2004) [Pubmed]
  17. Pharmacologic restoration of the early insulin response in pre-diabetic monkeys controls mealtime glucose excursions without peripheral hyperinsulinaemia. Dunning, B.E., Deacon, R., Gutierrez, C., Paladini, S., Valentin, M.A., Foley, J.E. Diabetologia (2003) [Pubmed]
  18. Bioavailability and pharmacokinetics of dehydroepiandrosterone in the cynomolgus monkey. Leblanc, M., Labrie, C., Bélanger, A., Candas, B., Labrie, F. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  19. Menstrual cycle characteristics in chronically hemiovariectomized cynomolgus monkeys (Macaca fascicularis). Goodman, A.L., Hodgen, G.D. J. Clin. Endocrinol. Metab. (1979) [Pubmed]
  20. The role of 5-lipoxygenase products in preclinical models of asthma. Wegner, C.D., Gundel, R.H., Abraham, W.M., Schulman, E.S., Kontny, M.J., Lazer, E.S., Homon, C.A., Graham, A.G., Torcellini, C.A., Clarke, C.C. J. Allergy Clin. Immunol. (1993) [Pubmed]
  21. Ovarian steroids differentially modulate the gene expression of gonadotropin-releasing hormone neuronal subtypes in the ovariectomized cynomolgus monkey. Krajewski, S.J., Abel, T.W., Voytko, M.L., Rance, N.E. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  22. Plasma lipid transfer protein as a determinant of the atherogenicity of monkey plasma lipoproteins. Quinet, E., Tall, A., Ramakrishnan, R., Rudel, L. J. Clin. Invest. (1991) [Pubmed]
  23. Primates highly responsive to dietary cholesterol up-regulate hepatic ACAT2, and less responsive primates do not. Rudel, L.L., Davis, M., Sawyer, J., Shah, R., Wallace, J. J. Biol. Chem. (2002) [Pubmed]
  24. Biosynthesis of 18(RD)-hydroxyeicosatetraenoic acid from arachidonic acid by microsomes of monkey seminal vesicles. Some properties of a novel fatty acid omega 3-hydroxylase and omega 3-epoxygenase. Oliw, E.H. J. Biol. Chem. (1989) [Pubmed]
  25. Drug-induced expansion and differentiation of V gamma 9V delta 2 T cells in vivo: the role of exogenous IL-2. Casetti, R., Perretta, G., Taglioni, A., Mattei, M., Colizzi, V., Dieli, F., D'Offizi, G., Malkovsky, M., Poccia, F. J. Immunol. (2005) [Pubmed]
  26. Lipoprotein metabolism during acute inhibition of hepatic triglyceride lipase in the cynomolgus monkey. Goldberg, I.J., Le, N.A., Paterniti, J.R., Ginsberg, H.N., Lindgren, F.T., Brown, W.V. J. Clin. Invest. (1982) [Pubmed]
  27. Induction of renal tumors in cynomolgus monkeys (Macaca fascicularis) by prenatal exposure to 1,2-dimethylhydrazine. Beniashvili, D.S. J. Natl. Cancer Inst. (1989) [Pubmed]
  28. Behavioral depression and positron emission tomography-determined serotonin 1A receptor binding potential in cynomolgus monkeys. Shively, C.A., Friedman, D.P., Gage, H.D., Bounds, M.C., Brown-Proctor, C., Blair, J.B., Henderson, J.A., Smith, M.A., Buchheimer, N. Arch. Gen. Psychiatry (2006) [Pubmed]
  29. Substituted benzamides as ligands for visualization of dopamine receptor binding in the human brain by positron emission tomography. Farde, L., Ehrin, E., Eriksson, L., Greitz, T., Hall, H., Hedström, C.G., Litton, J.E., Sedvall, G. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  30. Inhibition of coronary atherosclerosis by propranolol in behaviorally predisposed monkeys fed an atherogenic diet. Kaplan, J.R., Manuck, S.B., Adams, M.R., Weingand, K.W., Clarkson, T.B. Circulation (1987) [Pubmed]
  31. Generation and characterization of LymphoStat-B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator. Baker, K.P., Edwards, B.M., Main, S.H., Choi, G.H., Wager, R.E., Halpern, W.G., Lappin, P.B., Riccobene, T., Abramian, D., Sekut, L., Sturm, B., Poortman, C., Minter, R.R., Dobson, C.L., Williams, E., Carmen, S., Smith, R., Roschke, V., Hilbert, D.M., Vaughan, T.J., Albert, V.R. Arthritis Rheum. (2003) [Pubmed]
  32. Receptors and actions of corticotropin-releasing hormone in the primate pituitary gland. Millan, M.A., Samra, A.B., Wynn, P.C., Catt, K.J., Aguilera, G. J. Clin. Endocrinol. Metab. (1987) [Pubmed]
  33. Cytochromes P450 in cynomolgus monkeys mutagenically activate 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) but not 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx). Sadrieh, N., Snyderwine, E.G. Carcinogenesis (1995) [Pubmed]
  34. Contribution of CYP1A1 and CYP1A2 to the activation of heterocyclic amines in monkeys and human. Edwards, R.J., Murray, B.P., Murray, S., Schulz, T., Neubert, D., Gant, T.W., Thorgeirsson, S.S., Boobis, A.R., Davies, D.S. Carcinogenesis (1994) [Pubmed]
  35. Cocaine alters cerebral metabolism within the ventral striatum and limbic cortex of monkeys. Lyons, D., Friedman, D.P., Nader, M.A., Porrino, L.J. J. Neurosci. (1996) [Pubmed]
  36. Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific T cell responses. Fanales-Belasio, E., Moretti, S., Nappi, F., Barillari, G., Micheletti, F., Cafaro, A., Ensoli, B. J. Immunol. (2002) [Pubmed]
  37. Remodeling of the major pig xenoantigen by N-acetylglucosaminyltransferase III in transgenic pig. Miyagawa, S., Murakami, H., Takahagi, Y., Nakai, R., Yamada, M., Murase, A., Koyota, S., Koma, M., Matsunami, K., Fukuta, D., Fujimura, T., Shigehisa, T., Okabe, M., Nagashima, H., Shirakura, R., Taniguchi, N. J. Biol. Chem. (2001) [Pubmed]
  38. Apolipoprotein E4 and beta amyloid in senile plaques and cerebral blood vessels of aged rhesus monkeys. Poduri, A., Gearing, M., Rebeck, G.W., Mirra, S.S., Tigges, J., Hyman, B.T. Am. J. Pathol. (1994) [Pubmed]
  39. Reductions in bone mass, structure, and strength in axial and appendicular skeletons associated with increased turnover after ovariectomy in mature cynomolgus monkeys and preventive effects of clodronate. Itoh, F., Kojima, M., Furihata-Komatsu, H., Aoyagi, S., Kusama, H., Komatsu, H., Nakamura, T. J. Bone Miner. Res. (2002) [Pubmed]
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