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Chemical Compound Review:

Purinogen 2-[[(2R,3S,4R,5R)-5-(6- aminopurin-9-yl)-4...

Synonyms: PG-ATP, AC1MIWJO, (PG-ATP)n, 124199-67-3, Phosphoglyceroyl-ATP, ...

Culic, O. et al., Patel, B. et al.

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Disease relevance of Oligo-phosphoglyceroyl-ATP

We called this polymer purinogen and devised a means of assaying it quantitively [Patel, B., Sarcina, M. & Mowbray, J. (1994) Eur. J. Biochem. 220, 663-669] [1].

High impact information on Oligo-phosphoglyceroyl-ATP

We tested the possibility that a phosphoglyceroyl-ATP-containing polymer, purinogen, might support PAEC hibernation induced by lack of exogenous substrate [2].
Purinogen is not an endogenous substrate used in endothelial cells during substrate deprivation [2].

Analytical, diagnostic and therapeutic context of Oligo-phosphoglyceroyl-ATP

This involved isolation of the acid-insoluble fraction of PAEC, which was presumed to contain purinogen, and analysis by HPLC and 31P NMR [2].
The purinogen content was unchanged by ischaemia or reperfusion implying the existence of some other unidentified storage pool [1].

References

The mitochondrial phosphoglyceroyl-ATP-containing polymer, purinogen, is unchanged by cardiac ischaemia and reperfusion but may function in the regulation of free intracellular inorganic phosphate concentrations. Patel, B., Berhane, Y., Petrovic, A., Mowbray, J. Eur. J. Biochem. (1998) [Pubmed]
Purinogen is not an endogenous substrate used in endothelial cells during substrate deprivation. Culic, O., Decking, U.K., Bergschneider, E., Schrader, J. Biochem. J. (1999) [Pubmed]

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