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Chemical Compound Review

Muscarone     trimethyl-[(5-methyl-4-oxo- oxolan-2...

Synonyms: Allomuscarone, AGN-PC-0041VN, AC1MIY1P, 4780-69-2, 13552-60-8
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High impact information on Allomuscarone

  • MM2 calculations predicted a preferred gauche arrangement of the side chain for 1 and its analogues; such an arrangement was also observed in the solid state of muscarone picrate [1].
  • Structure-activity relationships are discussed in comparison with those for muscarone analogues [2].


  1. Conformational studies of muscarone analogues: X-ray analysis and molecular mechanics calculations. Carroll, P.J., De Amici, M., De Micheli, C., Toma, L. J. Med. Chem. (1992) [Pubmed]
  2. Synthesis and structure-activity studies of a series of 1-oxa-8-azaspiro[4.5]decanes as M1 muscarinic agonists. Tsukamoto, S., Fujii, M., Yasunaga, T., Matsuda, K., Wanibuchi, F., Hidaka, K., Furuya, T., Tamura, T. Chem. Pharm. Bull. (1995) [Pubmed]
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