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Chemical Compound Review:

Aldisine 5,8-diazabicyclo[5.3.0]deca- 9,11-diene-2,6...

Synonyms: Aldisin, CHEMBL357047, AG-G-87578, SureCN7844916, CHEBI:350317, ...

Tasdemir, D. et al., Roshak, A. et al.

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High impact information on Aldisine

Raf/MEK-1/MAPK cascade inhibitor activity-directed fractionation of the sponge Stylissa massa afforded eight known alkaloids: aldisine (1), 2-bromoaldisine (2), 10Z-debromohymenialdisine (3), 10E-hymenialdisine (4), 10Z-hymenialdisine (5), hymenin (6), oroidin (7), and 4,5-dibromopyrrole-2-carbonamide (8) [1].
Alternatively, both an analog, aldisine, and the protein kinase C inhibitor, RO 32-0432, were without affect [2].

Gene context of Aldisine

Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1) [1].

References

Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). Tasdemir, D., Mallon, R., Greenstein, M., Feldberg, L.R., Kim, S.C., Collins, K., Wojciechowicz, D., Mangalindan, G.C., Concepción, G.P., Harper, M.K., Ireland, C.M. J. Med. Chem. (2002) [Pubmed]
Inhibition of NFkappaB-mediated interleukin-1beta-stimulated prostaglandin E2 formation by the marine natural product hymenialdisine. Roshak, A., Jackson, J.R., Chabot-Fletcher, M., Marshall, L.A. J. Pharmacol. Exp. Ther. (1997) [Pubmed]

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