Gene Review:
MAP2K1 - mitogen-activated protein kinase kinase 1
Homo sapiens
Synonyms:
CFC3, Dual specificity mitogen-activated protein kinase kinase 1, ERK activator kinase 1, MAP kinase kinase 1, MAPK/ERK kinase 1, ...
- Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector. Orth, K., Palmer, L.E., Bao, Z.Q., Stewart, S., Rudolph, A.E., Bliska, J.B., Dixon, J.E. Science (1999)
- The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells. Sumimoto, H., Imabayashi, F., Iwata, T., Kawakami, Y. J. Exp. Med. (2006)
- Signal transduction pathways involved in soluble fractalkine-induced monocytic cell adhesion. Cambien, B., Pomeranz, M., Schmid-Antomarchi, H., Millet, M.A., Breittmayer, V., Rossi, B., Schmid-Alliana, A. Blood (2001)
- Cell-cycle-dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling. Morgan, M.A., Dolp, O., Reuter, C.W. Blood (2001)
- Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukemia cells to lovastatin-induced apoptosis. Wu, J., Wong, W.W., Khosravi, F., Minden, M.D., Penn, L.Z. Cancer Res. (2004)
- Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease. Mei, M., Su, B., Harrison, K., Chao, M., Siedlak, S.L., Previll, L.A., Jackson, L., Cai, D.X., Zhu, X. J. Neurochem. (2006)
- Cell death signaling in the cerebellum in Creutzfeldt-Jakob disease. Puig, B., Ferrer, I. Acta Neuropathol. (2001)
- Cdc2 kinase directly phosphorylates the cis-Golgi matrix protein GM130 and is required for Golgi fragmentation in mitosis. Lowe, M., Rabouille, C., Nakamura, N., Watson, R., Jackman, M., Jämsä, E., Rahman, D., Pappin, D.J., Warren, G. Cell (1998)
- Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors. Wan, Y., Kurosaki, T., Huang, X.Y. Nature (1996)
- Phosphorylation of Raf by ceramide-activated protein kinase. Yao, B., Zhang, Y., Delikat, S., Mathias, S., Basu, S., Kolesnick, R. Nature (1995)
- MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. Schaeffer, H.J., Catling, A.D., Eblen, S.T., Collier, L.S., Krauss, A., Weber, M.J. Science (1998)
- Mitogen-activated protein kinase pathway-dependent tumor-specific survival signaling in melanoma cells through inactivation of the proapoptotic protein bad. Eisenmann, K.M., VanBrocklin, M.W., Staffend, N.A., Kitchen, S.M., Koo, H.M. Cancer Res. (2003)
- Opposing roles for ERK1/2 in neuronal oxidative toxicity: distinct mechanisms of ERK1/2 action at early versus late phases of oxidative stress. Luo, Y., DeFranco, D.B. J. Biol. Chem. (2006)
- Activation of mitogen-activated protein kinases is required for alpha1-adrenergic agonist-induced cell scattering in transfected HepG2 cells. Spector, M., Nguyen, V.A., Sheng, X., He, L., Woodward, J., Fan, S., Baumgarten, C.M., Kunos, G., Dent, P., Gao, B. Exp. Cell Res. (2000)
- The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells. Nguyen, T.T., Tran, E., Nguyen, T.H., Do, P.T., Huynh, T.H., Huynh, H. Carcinogenesis (2004)
- p38mapk and MEK1/2 inhibition contribute to cellular oxidant injury after hypoxia. Powell, C.S., Wright, M.M., Jackson, R.M. Am. J. Physiol. Lung Cell Mol. Physiol. (2004)
- Chromosome mapping of the human genes encoding the MAP kinase kinase MEK1 (MAP2K1) to 15q21 and MEK2 (MAP2K2) to 7q32. Meloche, S., Gopalbhai, K., Beatty, B.G., Scherer, S.W., Pellerin, J. Cytogenet. Cell Genet. (2000)
- Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Dérijard, B., Raingeaud, J., Barrett, T., Wu, I.H., Han, J., Ulevitch, R.J., Davis, R.J. Science (1995)
- Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases. Takekawa, M., Tatebayashi, K., Saito, H. Mol. Cell (2005)
- Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1). Pagès, G., Brunet, A., L'Allemain, G., Pouysségur, J. EMBO J. (1994)
- Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways. Xiao, G.H., Jeffers, M., Bellacosa, A., Mitsuuchi, Y., Vande Woude , G.F., Testa, J.R. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Exogenous nitric oxide stimulates cell proliferation via activation of a mitogen-activated protein kinase pathway in ovine fetoplacental artery endothelial cells. Zheng, J., Wen, Y., Austin, J.L., Chen, D.B. Biol. Reprod. (2006)
- Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides. Schirmer, A., Kennedy, J., Murli, S., Reid, R., Santi, D.V. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds. Luttrell, L.M., Roudabush, F.L., Choy, E.W., Miller, W.E., Field, M.E., Pierce, K.L., Lefkowitz, R.J. Proc. Natl. Acad. Sci. U.S.A. (2001)
- B-Raf acts via the ROCKII/LIMK/cofilin pathway to maintain actin stress fibers in fibroblasts. Pritchard, C.A., Hayes, L., Wojnowski, L., Zimmer, A., Marais, R.M., Norman, J.C. Mol. Cell. Biol. (2004)
- Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals. von Gise, A., Lorenz, P., Wellbrock, C., Hemmings, B., Berberich-Siebelt, F., Rapp, U.R., Troppmair, J. Mol. Cell. Biol. (2001)
- Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression. Guha, M., O'Connell, M.A., Pawlinski, R., Hollis, A., McGovern, P., Yan, S.F., Stern, D., Mackman, N. Blood (2001)
- Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways. Jia, W., Yu, C., Rahmani, M., Krystal, G., Sausville, E.A., Dent, P., Grant, S. Blood (2003)
- MEK1-induced Golgi dynamics during cell cycle progression is partly mediated by Polo-like kinase-3. Xie, S., Wang, Q., Ruan, Q., Liu, T., Jhanwar-Uniyal, M., Guan, K., Dai, W. Oncogene (2004)
- The MEK1 proline-rich insert is required for efficient activation of the mitogen-activated protein kinases ERK1 and ERK2 in mammalian cells. Dang, A., Frost, J.A., Cobb, M.H. J. Biol. Chem. (1998)
- MEK partner 1 (MP1): regulation of oligomerization in MAP kinase signaling. Sharma, C., Vomastek, T., Tarcsafalvi, A., Catling, A.D., Schaeffer, H.J., Eblen, S.T., Weber, M.J. J. Cell. Biochem. (2005)
- Ouabain Binds with High Affinity to the Na,K-ATPase in Human Polycystic Kidney Cells and Induces Extracellular Signal-Regulated Kinase Activation and Cell Proliferation. Nguyen, A.N., Wallace, D.P., Blanco, G. J. Am. Soc. Nephrol. (2007)
- Hydrophobic as well as charged residues in both MEK1 and ERK2 are important for their proper docking. Xu Be, n.u.l.l., Stippec, S., Robinson, F.L., Cobb, M.H. J. Biol. Chem. (2001)
- Mechanistic studies of the dual phosphorylation of mitogen-activated protein kinase. Ferrell, J.E., Bhatt, R.R. J. Biol. Chem. (1997)
- Identification of a C-terminal region that regulates mitogen-activated protein kinase kinase-1 cytoplasmic localization and ERK activation. Cha, H., Lee, E.K., Shapiro, P. J. Biol. Chem. (2001)
- Cross-talk between JNK/SAPK and ERK/MAPK pathways: sustained activation of JNK blocks ERK activation by mitogenic factors. Shen, Y.H., Godlewski, J., Zhu, J., Sathyanarayana, P., Leaner, V., Birrer, M.J., Rana, A., Tzivion, G. J. Biol. Chem. (2003)
- Trypanosoma cruzi infection activates extracellular signal-regulated kinase in cultured endothelial and smooth muscle cells. Mukherjee, S., Huang, H., Petkova, S.B., Albanese, C., Pestell, R.G., Braunstein, V.L., Christ, G.J., Wittner, M., Lisanti, M.P., Berman, J.W., Weiss, L.M., Tanowitz, H.B. Infect. Immun. (2004)
- The regulatory mechanism by which interleukin-6 stimulates GH-gene expression in rat GH3 cells. Gong, F.Y., Shi, Y.F., Deng, J.Y. J. Endocrinol. (2006)
- Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells. Wu, X., Noh, S.J., Zhou, G., Dixon, J.E., Guan, K.L. J. Biol. Chem. (1996)
- MEK is a key modulator for TLR5-induced interleukin-8 and MIP3alpha gene expression in non-transformed human colonic epithelial cells. Rhee, S.H., Keates, A.C., Moyer, M.P., Pothoulakis, C. J. Biol. Chem. (2004)
- MEK1-dependent delayed expression of Fos-related antigen-1 counteracts c-Fos and p65 NF-kappaB-mediated interleukin-8 transcription in response to cytokines or growth factors. Hoffmann, E., Thiefes, A., Buhrow, D., Dittrich-Breiholz, O., Schneider, H., Resch, K., Kracht, M. J. Biol. Chem. (2005)
- IQGAP1 is a scaffold for mitogen-activated protein kinase signaling. Roy, M., Li, Z., Sacks, D.B. Mol. Cell. Biol. (2005)
- Tumor Necrosis Factor-{alpha} Blocks Apoptosis in Melanoma Cells when BRAF Signaling Is Inhibited. Gray-Schopfer, V.C., Karasarides, M., Hayward, R., Marais, R. Cancer Res. (2007)
- Chemotactic peptide-induced activation of MEK-2, the predominant isoform in human neutrophils. Inhibition by wortmannin. Downey, G.P., Butler, J.R., Brumell, J., Borregaard, N., Kjeldsen, L., Sue-A-Quan, A.K., Grinstein, S. J. Biol. Chem. (1996)
- Loss of SMEK, a novel, conserved protein, suppresses MEK1 null cell polarity, chemotaxis, and gene expression defects. Mendoza, M.C., Du, F., Iranfar, N., Tang, N., Ma, H., Loomis, W.F., Firtel, R.A. Mol. Cell. Biol. (2005)
- Phosphorylated protein kinases associated with neuronal and glial tau deposits in argyrophilic grain disease. Ferrer, I., Barrachina, M., Tolnay, M., Rey, M.J., Vidal, N., Carmona, M., Blanco, R., Puig, B. Brain Pathol. (2003)
- Enhanced activation of mitogen-activated protein kinase and myosin light chain kinase by the Pro33 polymorphism of integrin beta 3. Vijayan, K.V., Liu, Y., Dong, J.F., Bray, P.F. J. Biol. Chem. (2003)
- Identification of a novel inhibitor of mitogen-activated protein kinase kinase. Favata, M.F., Horiuchi, K.Y., Manos, E.J., Daulerio, A.J., Stradley, D.A., Feeser, W.S., Van Dyk, D.E., Pitts, W.J., Earl, R.A., Hobbs, F., Copeland, R.A., Magolda, R.L., Scherle, P.A., Trzaskos, J.M. J. Biol. Chem. (1998)