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Chemical Compound Review

Zankiren     (2R)-2-benzyl-N-[(1S)-1- [[(2S,3R,4S)-1...

Synonyms: CHEMBL113841, SureCN180700, CHEBI:288763, DNC009742, A-72517, ...
 
 
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High impact information on Zankiren

  • Dose-dependent effects of the renin inhibitor zankiren HCl after a single oral dose in mildly sodium-depleted normotensive subjects [1].
 

Analytical, diagnostic and therapeutic context of Zankiren

  • To determine whether previous findings were reflective of the renin inhibitor class, we studied 12 healthy men on a sodium-restricted diet, each of whom received two or three escalating oral doses of zankiren, a new agent [2].

References

  1. Dose-dependent effects of the renin inhibitor zankiren HCl after a single oral dose in mildly sodium-depleted normotensive subjects. Ménard, J., Boger, R.S., Moyse, D.M., Guyene, T.T., Glassman, H.N., Kleinert, H.D. Circulation (1995) [Pubmed]
  2. Renal vascular responses to renin inhibition with zankiren in men. Fisher, N.D., Hollenberg, N. Clin. Pharmacol. Ther. (1995) [Pubmed]
 
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