Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC-11380 [6-[2-chloro-1-[(1-methyl-4- propyl...

Synonyms: AKOS015960484, AC1L1O0X, ST075182, I06-0114, 24729-96-2, ...

Liao, Z. et al., Blenkharn, J.I. et al.

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High impact information on Clindamycin phosphate

To our knowledge, aminoglycoside antibiotics and the ribosome inhibitors thiostrepton, clindamycin-2-phosphate, and puromycin are the first reported pharmacological Tdp1 inhibitors [1].
Localized inhibition of clindamycin-2-phosphate hydrolysis due to product inhibition by inorganic phosphate [2].

References

Inhibition of human tyrosyl-DNA phosphodiesterase by aminoglycoside antibiotics and ribosome inhibitors. Liao, Z., Thibaut, L., Jobson, A., Pommier, Y. Mol. Pharmacol. (2006) [Pubmed]
Localized inhibition of clindamycin-2-phosphate hydrolysis due to product inhibition by inorganic phosphate. Blenkharn, J.I., Darrell, J.H. J. Antimicrob. Chemother. (1981) [Pubmed]

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