Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Oxo-Endoxan 2-[bis(2-chloroethyl)amino]- 2-oxo-1-oxa-3...

Synonyms: CCRIS 5128, Asta 5160, NSC-139488, NSC139488, LS-100939, ...

Hadidi, A.H. et al., Balbinder, E. et al., Hadidi, A.H. et al.

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High impact information on C07644

Neither 4-ketocyclophosphamide nor nor-nitrogen mustard excretion differed between LC and HC phenotypes; however, HC patients had a greater excretion of cyclophosphamide (46.4 +/- 15.5 relative percentage) than LC patients (19.4 +/- 12.6%) [1].
All four acted as direct base substitution mutagens although 4-ketocyclophosphamide showed an increase in mutagenicity after metabolic activation with S-9 rat liver fraction [2].
The method was validated for cyclophosphamide and 4-oxocyclophosphamide using gas chromatography [3].

References

Phenotypically deficient urinary elimination of carboxyphosphamide after cyclophosphamide administration to cancer patients. Hadidi, A.H., Coulter, C.E., Idle, J.R. Cancer Res. (1988) [Pubmed]
Relative mutagenicity of some urinary metabolites of the antitumor drug cyclophosphamide. Balbinder, E., Reich, C.I., Shugarts, D., Keogh, J., Fibiger, R., Jones, T., Banks, A. Cancer Res. (1981) [Pubmed]
Combined thin-layer chromatography-photography-densitometry for the quantitation of cyclophosphamide and its four principal urinary metabolites. Hadidi, A.H., Idle, J.R. J. Chromatogr. (1988) [Pubmed]

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