Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1L1QN6 1,2-dimethoxybenzene; 1,3...

Synonyms:

Ono, M. et al., Turk, Z. et al.

Turk, Nemet, Varga-Defteardarović, Car,

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Disease relevance of DIMETHOXYBENZENE

FP-21399 is a novel compound of the bis(disulfonaphthalene) dimethoxybenzene class that blocks entry of HIV into CD4+ cells and blocks fusion of infected and noninfected CD4+ cells [1].

High impact information on DIMETHOXYBENZENE

The methylglyoxal assay, based on methylglyoxal derivation with 1,2-diamino-4,5-dimethoxybenzene (DDB), was performed by HPLC, only assessing the level of free methylglyoxal [2].

References

FP-21399 blocks HIV envelope protein-mediated membrane fusion and concentrates in lymph nodes. Ono, M., Wada, Y., Wu, Y., Nemori, R., Jinbo, Y., Wang, H., Lo, K.M., Yamaguchi, N., Brunkhorst, B., Otomo, H., Wesolowski, J., Way, J.C., Itoh, I., Gillies, S., Chen, L.B. Nat. Biotechnol. (1997) [Pubmed]
Elevated level of methylglyoxal during diabetic ketoacidosis and its recovery phase. Turk, Z., Nemet, I., Varga-Defteardarović, L., Car, N. Diabetes Metab. (2006) [Pubmed]

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