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Chemical Compound Review

AC1MQSAH     4-[2-(5,5,8,8-tetramethyl- 6,7...

Synonyms: BMS649
This record was replaced with 127019.
 
 
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High impact information on SR 11237

  • Overexpression of RXR in GH4C1 cells, as well as incubation with BMS649 (a RXR-specific ligand), increased the inhibitory effect of vitamin D, suggesting that the VDR/RXR heterodimer is the repressive species and that titration of RXR is not responsible for this inhibition [1].
  • Because CYP26A1 expression could not be induced by RAR ligands alone, NB4 cells were then co-treated with the RXR agonist BMS649 [2].

References

 
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