The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Titrimetry


Psychiatry related information on Titrimetry

  • We conclude that if during CPAP titration the end point is the disappearance of arousals, most patients with SAHS will still exhibit periods of high intrathoracic pressures with limited inspiratory flow [6].
  • As a secondary analysis, we analyzed auto-CPAP performance with regard to sleep-stage distribution and arousals in a group of nine male patients, and compared it with the previous group of 20 patients in which manually CPAP titration was guided by PSG [7].
  • Rats receiving dose titrations of tolvaptan (0.25, 0.5, 1, 2, 4, and 8 mg/kg) increased plasma sodium to healthy levels without causing abnormal animal behavior suggesting neurological symptoms or death, improved hyponatremia-driven increases in wet weight and water content in the organs [8].
  • A dose titration, and an open 6-week efficacy and safety study of desmopressin tablets in the management of nocturnal enuresis [9].
  • Withdrawal symptoms in long term benzodiazepine users and seizures in patients who have taken an overdose of TCA or carbamazepine and a benzodiazepine can occur with flumazenil; these symptoms are avoidable by utilising slow flumazenil dose titration [10].

High impact information on Titrimetry

  • The crystallographic structure as well as pH titration studies and mutagenesis of an active site cysteine suggest a catalytic mechanism that includes general acid-base and covalent catalysis during peptide bond isomerization [11].
  • Using isothermal titration calorimetry, we show that acidic FGF (aFGF) forms a 1:1 complex with the soluble extracellular domain of FGF receptor (FGFR) [12].
  • After individual dose titration, the mean daily doses of the drugs were as follows: amitriptyline, 105 mg; desipramine, 111 mg; and fluoxetine, 40 mg [13].
  • Using pH titration and amino acid replacements, we also show that destabilization of the Fos homodimer by acidic residues provides a major thermodynamic driving force for preferential heterodimer formation [14].
  • Deletion of arginine 156 resulted in a peptide that was shown to be greatly superior in both dose response titrations and in its rate of association with cells to form targets [15].

Chemical compound and disease context of Titrimetry

  • It is concluded that the currently used omeprazole maintenance doses in patients with Zollinger-Ellison syndrome are too high and advocated that the initial dose still be established by acute daily upward titration followed by gradual reduction once control of acid output has been achieved [1].
  • Fluorescence titrations and ODMR results indicate that tryptophans 40 and 54 are the only tryptophan residues in E. coli single-stranded DNA binding protein that are involved in stabilizing the protein-nucleic acid complexes via stacking interactions [16].
  • By using isothermal titration calorimetry and stopped-flow spectrofluorometry, we directly examined metal binding to a highly conserved aspartate in the Escherichia coli CDF transporter YiiP (FieF) [17].
  • Isothermal titration calorimetry has been used to investigate the thermodynamic parameters of the binding of thymidine (dT) and ATP to herpes simplex virus type 1 thymidine kinase (HSV1 TK) [18].
  • The coordination chemistry of an extracellular siderophore produced by Mycobacterium neoaurum, exochelin MN (ExoMN), is reported along with its pK(a) values, Fe(III) and Fe(II) chelation constants, and aqueous solution speciation as determined by spectrophotometric and potentiometric titration techniques [19].

Biological context of Titrimetry


Anatomical context of Titrimetry

  • It seems probable that a requirement for abrogation of Fv-1b restriction by a single infectious particle of N tropic MuLV, which does not itself replicate, is responsible for the two-hit dose-response relationship observed in infectivity titrations of N tropic MuLV in Balb/3T3 cells [25].
  • Intravenous infusion of neurotensin at 25 pmol X kg-1 h-1 during 2 h, however, failed to significantly inhibit peptone meal-stimulated gastric acid secretion measured by intragastric titration [26].
  • Bovine aortic endothelial cell (BAEC) attachments to laminin, fibronectin, and fibrinogen are inhibited by soluble arginine-glycine-aspartate (RGD)-containing peptides, and YGRGDSP activity is responsive to titration of either soluble peptide or matrix protein [27].
  • Although this biosynthetic pathway occurs independently of cell-cell contact, induction of cell-cell contact results in dramatic increases in the efficiency and rate of titration of DGI from the soluble to the insoluble pool, and its transport to the plasma membrane where DGI becomes metabolically stable (t1/2 greater than 24 h) [28].
  • In a normoxic-anoxic titration, an increment of 50% in the reduction of pyridine nucleotide in intact tissue corresponds to the point at which the mitochondria are half-maximally active in energy coupling [29].

Associations of Titrimetry with chemical compounds

  • When antacid titration was added to the cimetidine regimen in four of seven patients with bleeding, all four stopped bleeding [30].
  • Chemical shift changes upon titration with histone H3 peptides indicate a binding site at the domain boundary opposite to the coenzyme A site [31].
  • From NMR titrations of wild-type and engineered mutants we find that the pKa of His18 is 7.9 in wild-type enzyme, 1.6 units above the value in the urea-denatured enzyme and in model peptides [32].
  • Redox titrations with molecular oxygen (O2) and cobaltocene were carried out, and O2 was found to bind irreversibly in a 1:1 ratio to the model compound [33].
  • Potentiometric titrations of rabbit antibody to the hapten trimethylphenylammonium ion demonstrate the speed and convenience of the new method for the determination of binding equilibria [34].

Gene context of Titrimetry

  • We suggest that this inhibition, which we call squelching, reflects titration of a transcription factor by the activating region of GAL4 [35].
  • RAD51 relieved the negative dominance of each of these alleles either by competitive titration or functional activation of mutant or heterologous Rad52 proteins [36].
  • We have observed that the transcription of several genes, including ftz, is triggered in embryos at a critical nuclear density; therefore, we suggest that titration of transcription factors like ttk by the nucleocytoplasmic ratio triggers zygotic transcription in Drosophila [37].
  • Both complexes are heterotrimers, comprising two phosphorylated R-Smad subunits and one Smad4 subunit, a finding that was corroborated by isothermal titration calorimetry and mutational studies [38].
  • Upon titration with DNA, resonance shifts in the backbone and Asn and Gln side-chain amides indicate that helix 3 acts as the recognition helix of the heat shock transcription factor [39].

Analytical, diagnostic and therapeutic context of Titrimetry


  1. Currently used doses of omeprazole in Zollinger-Ellison syndrome are too high. Metz, D.C., Pisegna, J.R., Fishbeyn, V.A., Benya, R.V., Feigenbaum, K.M., Koviack, P.D., Jensen, R.T. Gastroenterology (1992) [Pubmed]
  2. Transcription antitermination regulation of the Pseudomonas aeruginosa amidase operon. Wilson, S.A., Wachira, S.J., Norman, R.A., Pearl, L.H., Drew, R.E. EMBO J. (1996) [Pubmed]
  3. Low-dose captopril titration in patients with moderate-to-severe hypertension treated with diuretics. Thind, G.S., Mahapatra, R.K., Johnson, A., Coleman, R.D. Circulation (1983) [Pubmed]
  4. Diltiazem, nifedipine, and their combination in patients with stable angina pectoris: effects on angina, exercise tolerance, and the ambulatory electrocardiographic ST segment. Frishman, W., Charlap, S., Kimmel, B., Teicher, M., Cinnamon, J., Allen, L., Strom, J. Circulation (1988) [Pubmed]
  5. Epstein-Barr nuclear antigen 1 mediates a DNA loop within the latent replication origin of Epstein-Barr virus. Frappier, L., O'Donnell, M. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  6. Time-course of stepwise CPAP titration. Behavior of respiratory and neurological variables. Montserrat, J.M., Ballester, E., Olivi, H., Reolid, A., Lloberes, P., Morello, A., Rodriguez-Roisin, R. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  7. Comparison of manual and automatic CPAP titration in patients with sleep apnea/hypopnea syndrome. Lloberes, P., Ballester, E., Montserrat, J.M., Botifoll, E., Ramirez, A., Reolid, A., Gistau, C., Rodriguez-Roisin, R. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  8. Therapeutic effects of tolvaptan, a potent, selective nonpeptide vasopressin V2 receptor antagonist, in rats with acute and chronic severe hyponatremia. Miyazaki, T., Yamamura, Y., Onogawa, T., Nakamura, S., Kinoshita, S., Nakayama, S., Fujiki, H., Mori, T. Endocrinology (2005) [Pubmed]
  9. A dose titration, and an open 6-week efficacy and safety study of desmopressin tablets in the management of nocturnal enuresis. Matthiesen, T.B., Rittig, S., Djurhuus, J.C., Nørgaard, J.P. J. Urol. (1994) [Pubmed]
  10. A risk-benefit assessment of flumazenil in the management of benzodiazepine overdose. Weinbroum, A.A., Flaishon, R., Sorkine, P., Szold, O., Rudick, V. Drug safety : an international journal of medical toxicology and drug experience. (1997) [Pubmed]
  11. Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent. Ranganathan, R., Lu, K.P., Hunter, T., Noel, J.P. Cell (1997) [Pubmed]
  12. Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation. Spivak-Kroizman, T., Lemmon, M.A., Dikic, I., Ladbury, J.E., Pinchasi, D., Huang, J., Jaye, M., Crumley, G., Schlessinger, J., Lax, I. Cell (1994) [Pubmed]
  13. Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. Max, M.B., Lynch, S.A., Muir, J., Shoaf, S.E., Smoller, B., Dubner, R. N. Engl. J. Med. (1992) [Pubmed]
  14. Mechanism of specificity in the Fos-Jun oncoprotein heterodimer. O'Shea, E.K., Rutkowski, R., Kim, P.S. Cell (1992) [Pubmed]
  15. Enhanced recognition of a modified peptide antigen by cytotoxic T cells specific for influenza nucleoprotein. Bodmer, H.C., Pemberton, R.M., Rothbard, J.B., Askonas, B.A. Cell (1988) [Pubmed]
  16. Investigation of the role of individual tryptophan residues in the binding of Escherichia coli single-stranded DNA binding protein to single-stranded polynucleotides. A study by optical detection of magnetic resonance and site-selected mutagenesis. Khamis, M.I., Casas-Finet, J.R., Maki, A.H., Murphy, J.B., Chase, J.W. J. Biol. Chem. (1987) [Pubmed]
  17. Selective metal binding to a membrane-embedded aspartate in the Escherichia coli metal transporter YiiP (FieF). Wei, Y., Fu, D. J. Biol. Chem. (2005) [Pubmed]
  18. Compulsory order of substrate binding to herpes simplex virus type 1 thymidine kinase. A calorimetric study. Perozzo, R., Jelesarov, I., Bosshard, H.R., Folkers, G., Scapozza, L. J. Biol. Chem. (2000) [Pubmed]
  19. Iron chelation properties of an extracellular siderophore exochelin MN. Dhungana, S., Miller, M.J., Dong, L., Ratledge, C., Crumbliss, A.L. J. Am. Chem. Soc. (2003) [Pubmed]
  20. Comparisons of the chemical and biologic properties of triaziquone and triaziquone-protein conjugates. Linford, J.H., Froese, G. J. Natl. Cancer Inst. (1978) [Pubmed]
  21. Analysis of gene expression in mouse preimplantation embryos demonstrates that the primary role of enhancers is to relieve repression of promoters. Majumder, S., Miranda, M., DePamphilis, M.L. EMBO J. (1993) [Pubmed]
  22. Different susceptibility to the development of nitroglycerin tolerance in the arterial and venous circulation in humans. Effects of N-acetylcysteine administration. Ghio, S., de Servi, S., Perotti, R., Eleuteri, E., Montemartini, C., Specchia, G. Circulation (1992) [Pubmed]
  23. Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20. Luo, X., Fang, G., Coldiron, M., Lin, Y., Yu, H., Kirschner, M.W., Wagner, G. Nat. Struct. Biol. (2000) [Pubmed]
  24. Toward genetic dissection of high and low antibody responsiveness in Biozzi mice. Puel, A., Mevel, J.C., Bouthillier, Y., Feingold, N., Fridman, W.H., Mouton, D. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  25. Loss of Fv-1 restriction in Balb/3T3 cells following infection with a single N tropic murine leukemia virus particle. Duran-Troise, G., Bassin, R.H., Rein, A., Gerwin, B.I. Cell (1977) [Pubmed]
  26. Regulation of gastric acid secretion by neurotensin in man. Evidence against a hormonal role. Mogard, M.H., Maxwell, V., Sytnik, B., Walsh, J.H. J. Clin. Invest. (1987) [Pubmed]
  27. Spatiotemporal segregation of endothelial cell integrin and nonintegrin extracellular matrix-binding proteins during adhesion events. Basson, C.T., Knowles, W.J., Bell, L., Albelda, S.M., Castronovo, V., Liotta, L.A., Madri, J.A. J. Cell Biol. (1990) [Pubmed]
  28. Regulation of desmosome assembly in epithelial cells: kinetics of synthesis, transport, and stabilization of desmoglein I, a major protein of the membrane core domain. Pasdar, M., Nelson, W.J. J. Cell Biol. (1989) [Pubmed]
  29. Pyridine nucleotide as an indicator of the oxygen requirements for energy-linked functions of mitochondria. Chance, B. Circ. Res. (1976) [Pubmed]
  30. Antacid versus cimetidine in preventing acute gastrointestinal bleeding. A randomized trial in 75 critically ill patients. Priebe, H.J., Skillman, J.J., Bushnell, L.S., Long, P.C., Silen, W. N. Engl. J. Med. (1980) [Pubmed]
  31. Solution structure of the catalytic domain of GCN5 histone acetyltransferase bound to coenzyme A. Lin, Y., Fletcher, C.M., Zhou, J., Allis, C.D., Wagner, G. Nature (1999) [Pubmed]
  32. Stabilization of protein structure by interaction of alpha-helix dipole with a charged side chain. Sali, D., Bycroft, M., Fersht, A.R. Nature (1988) [Pubmed]
  33. A functional model related to cytochrome c oxidase and its electrocatalytic four-electron reduction of O2. Collman, J.P., Fu, L., Herrmann, P.C., Zhang, X. Science (1997) [Pubmed]
  34. Antibody binding measurements with hapten-selective membrane electrodes. Meyerhoff, M., Rechnitz, G.A. Science (1977) [Pubmed]
  35. Negative effect of the transcriptional activator GAL4. Gill, G., Ptashne, M. Nature (1988) [Pubmed]
  36. Dominant negative alleles of RAD52 reveal a DNA repair/recombination complex including Rad51 and Rad52. Milne, G.T., Weaver, D.T. Genes Dev. (1993) [Pubmed]
  37. Activation of transcription in Drosophila embryos is a gradual process mediated by the nucleocytoplasmic ratio. Pritchard, D.K., Schubiger, G. Genes Dev. (1996) [Pubmed]
  38. Structural basis of heteromeric smad protein assembly in TGF-beta signaling. Chacko, B.M., Qin, B.Y., Tiwari, A., Shi, G., Lam, S., Hayward, L.J., De Caestecker, M., Lin, K. Mol. Cell (2004) [Pubmed]
  39. Solution structure of the DNA-binding domain of Drosophila heat shock transcription factor. Vuister, G.W., Kim, S.J., Orosz, A., Marquardt, J., Wu, C., Bax, A. Nat. Struct. Biol. (1994) [Pubmed]
  40. Gastric acid and gastrin response to decaffeinated coffee and a peptone meal. Feldman, E.J., Isenberg, J.I., Grossman, M.I. JAMA (1981) [Pubmed]
  41. Recognition of eIF4G by rotavirus NSP3 reveals a basis for mRNA circularization. Groft, C.M., Burley, S.K. Mol. Cell (2002) [Pubmed]
  42. Interleukin 7 generates antitumor cytotoxic T lymphocytes against murine sarcomas with efficacy in cellular adoptive immunotherapy. Jicha, D.L., Mulé, J.J., Rosenberg, S.A. J. Exp. Med. (1991) [Pubmed]
  43. Clinical and serological differences between systemic lupus erythematosus patients with antibodies to Ro versus patients with antibodies to Ro and La. Wasicek, C.A., Reichlin, M. J. Clin. Invest. (1982) [Pubmed]
  44. Double-blind randomised trial of a very-low-dose warfarin for prevention of thromboembolism in stage IV breast cancer. Levine, M., Hirsh, J., Gent, M., Arnold, A., Warr, D., Falanga, A., Samosh, M., Bramwell, V., Pritchard, K.I., Stewart, D. Lancet (1994) [Pubmed]
WikiGenes - Universities