Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AGN-PC-006147 1-(4-methoxyphenyl)prop-2-en- 1-ol

Synonyms: CHEMBL181994, CCRIS 1873, SureCN1689680, LS-7445, AKOS006279321, ...

Drinkwater, N.R. et al., Iyer, L.V. et al.

Iyer, Ho, Shinn, Bradford, Tanga, Nath, Green,

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Disease relevance of CCRIS 1873

Of the 12-month survivors given a total dose of 4.4 mumoles of 1'-hydroxyestragole, 70% developed hepatocellular carcinomas; the incidence in mice that received only the vehicle (trioctanoin) was 12% [1].

High impact information on CCRIS 1873

Glucuronidation of 1'-hydroxyestragole (1'-HE) by human UDP-glucuronosyltransferases UGT2B7 and UGT1A9 [2].

References

Hepatocarcinogenicity of estragole (1-allyl-4-methoxybenzene) and 1'-hydroxyestragole in the mouse and mutagenicity of 1'-acetoxyestragole in bacteria. Drinkwater, N.R., Miller, E.C., Miller, J.A., Pitot, H.C. J. Natl. Cancer Inst. (1976) [Pubmed]
Glucuronidation of 1'-hydroxyestragole (1'-HE) by human UDP-glucuronosyltransferases UGT2B7 and UGT1A9. Iyer, L.V., Ho, M.N., Shinn, W.M., Bradford, W.W., Tanga, M.J., Nath, S.S., Green, C.E. Toxicol. Sci. (2003) [Pubmed]

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