Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

malyl-CoA (2S)-3-[2-[3-[[4- [[[(2R,3S,4R,5R)-5-(6...

Synonyms: HMDB01021, AC1L992Z, Malyl-coenzyme A, L-Malyl-Coenzyme A, S-(3-carboxy-3-hydroxypropanoate, ...

Friedmann, S. et al., Herter, S. et al.

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Disease relevance of malyl-CoA

The putative L-malyl-CoA lyase gene of C. aurantiacus was cloned and expressed in Escherichia coli, and the recombinant enzyme was purified and studied [1].

High impact information on malyl-CoA

Based on the N-terminal amino acid sequence of its two subunits, the corresponding genes were identified on a gene cluster which also contains the gene for L-malyl-CoA lyase, the subsequent enzyme in the pathway [2].

References

L-Malyl-coenzyme A lyase/beta-methylmalyl-coenzyme A lyase from Chloroflexus aurantiacus, a bifunctional enzyme involved in autotrophic CO(2) fixation. Herter, S., Busch, A., Fuchs, G. J. Bacteriol. (2002) [Pubmed]
Properties of succinyl-coenzyme A:L-malate coenzyme A transferase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus. Friedmann, S., Steindorf, A., Alber, B.E., Fuchs, G. J. Bacteriol. (2006) [Pubmed]

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