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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Multigene Family

 
 
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Disease relevance of Multigene Family

 

Psychiatry related information on Multigene Family

 

High impact information on Multigene Family

 

Chemical compound and disease context of Multigene Family

 

Biological context of Multigene Family

  • We analysed a multigenerational family with WSN and found cosegregation of the disease with the keratin gene cluster on chromosome 17 [19].
  • The 9.0 kb histone gene clusters are not adjacent in the genome, but are separated from neighboring clusters by up to 50 kb or more of cluster spacer sequences; some or all of these spacer sequences are members of a predominantly centromeric satellite DNA with a 2235 bp repeating unit [20].
  • Haplotype analysis revealed that the affected son and daughter inherited different epsilon gamma delta beta-globin gene clusters from the father [21].
  • We show that the classical enhancer element, HS2 of the prototypical locus control region (LCR) of the beta-globin gene cluster, is in close physical proximity to an actively transcribed HBB (beta-globin) gene located over 50 kb away in vivo, suggesting a direct regulatory interaction [22].
  • One gene cluster mapped to the L region and a second cluster with seven genes to the Qa-2,3 region of the major histocompatibility complex [23].
 

Anatomical context of Multigene Family

  • In the rodent malaria agent P. yoelii yoelii, a multigene family codes for merozoite rhoptry proteins of relative molecular mass 235,000 (p235 proteins); these proteins are thought to determine the subset of erythrocytes that the parasites invade [24].
  • Two elements important for amplification of the third chromosome chorion gene cluster, ACE3 and Ori-beta, are directly bound by Orc (origin recognition complex), and two-dimensional gel analysis has revealed that the primary origin used is Ori-beta (refs 7-9) [25].
  • Most of the protein and glycoprotein components are products of members of multigene families, but show specialization for plaque formation and intermediate filament attachment [26].
  • We demonstrate here that primary myeloid progenitors immortalized by various MLL oncoproteins exhibit a characteristic Hoxa gene cluster expression profile, which reflects that preferentially expressed in the myeloid clonogenic progenitor fraction of normal bone marrow [27].
  • Cells in metaphase and telophase have no detectable focus. p220 foci contain cyclin E and are coincident with Cajal bodies (CBs), subnuclear organelles that associate with histone gene clusters on chromosomes 1 and 6 [28].
 

Associations of Multigene Family with chemical compounds

 

Gene context of Multigene Family

 

Analytical, diagnostic and therapeutic context of Multigene Family

References

  1. Epidermolytic palmoplantar keratoderma cosegregates with a keratin 9 mutation in a pedigree with breast and ovarian cancer. Torchard, D., Blanchet-Bardon, C., Serova, O., Langbein, L., Narod, S., Janin, N., Goguel, A.F., Bernheim, A., Franke, W.W., Lenoir, G.M. Nat. Genet. (1994) [Pubmed]
  2. Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice. Nishiguchi, S., Wood, H., Kondoh, H., Lovell-Badge, R., Episkopou, V. Genes Dev. (1998) [Pubmed]
  3. CcpA-dependent carbon catabolite repression in bacteria. Warner, J.B., Lolkema, J.S. Microbiol. Mol. Biol. Rev. (2003) [Pubmed]
  4. Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus. Wandstrat, A.E., Nguyen, C., Limaye, N., Chan, A.Y., Subramanian, S., Tian, X.H., Yim, Y.S., Pertsemlidis, A., Garner, H.R., Morel, L., Wakeland, E.K. Immunity (2004) [Pubmed]
  5. Epidermolytic hyperkeratosis (bullous congenital ichthyosiform erythroderma). Genetic linkage to chromosome 12q in the region of the type II keratin gene cluster. Pulkkinen, L., Christiano, A.M., Knowlton, R.G., Uitto, J. J. Clin. Invest. (1993) [Pubmed]
  6. Evolutionary dynamics of olfactory receptor genes in fishes and tetrapods. Niimura, Y., Nei, M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  7. Association of IL-1 RN*2 allele and methionine synthase 2756 AA genotype with dementia severity of sporadic Alzheimer's disease. Bosco, P., Guéant-Rodríguez, R.M., Anello, G., Romano, A., Namour, B., Spada, R.S., Caraci, F., Tringali, G., Ferri, R., Guéant, J.L. J. Neurol. Neurosurg. Psychiatr. (2004) [Pubmed]
  8. GABA-A receptor beta3 and alpha5 subunit gene cluster on chromosome 15q11-q13 and bipolar disorder: a genetic association study. Papadimitriou, G.N., Dikeos, D.G., Karadima, G., Avramopoulos, D., Daskalopoulou, E.G., Stefanis, C.N. Am. J. Med. Genet. (2001) [Pubmed]
  9. Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster. Liszewski, M.K., Post, T.W., Atkinson, J.P. Annu. Rev. Immunol. (1991) [Pubmed]
  10. Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome. Horike, S., Cai, S., Miyano, M., Cheng, J.F., Kohwi-Shigematsu, T. Nat. Genet. (2005) [Pubmed]
  11. Rhox: a new homeobox gene cluster. Maclean, J.A., Chen, M.A., Wayne, C.M., Bruce, S.R., Rao, M., Meistrich, M.L., Macleod, C., Wilkinson, M.F. Cell (2005) [Pubmed]
  12. Haplotype block structure of the cytochrome P450 CYP2C gene cluster on chromosome 10. Walton, R., Kimber, M., Rockett, K., Trafford, C., Kwiatkowski, D., Sirugo, G. Nat. Genet. (2005) [Pubmed]
  13. Homeobox galore: when reproduction goes RHOX and roll. Hogeveen, K.N., Sassone-Corsi, P. Cell (2005) [Pubmed]
  14. An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190. Kaneda, K., Kuzuyama, T., Takagi, M., Hayakawa, Y., Seto, H. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  15. Histidine regulation in Salmonella typhimurium: an activator attenuator model of gene regulation. Artz, S.W., Broach, J.R. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  16. Cloning and heterologous expression of a gene cluster for the biosynthesis of tetracenomycin C, the anthracycline antitumor antibiotic of Streptomyces glaucescens. Motamedi, H., Hutchinson, C.R. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  17. Pseudomonas aeruginosa possesses homologues of mammalian phenylalanine hydroxylase and 4 alpha-carbinolamine dehydratase/DCoH as part of a three-component gene cluster. Zhao, G., Xia, T., Song, J., Jensen, R.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  18. Cloning and expression of the gene cluster encoding key proteins involved in acetyl-CoA synthesis in Clostridium thermoaceticum: CO dehydrogenase, the corrinoid/Fe-S protein, and methyltransferase. Roberts, D.L., James-Hagstrom, J.E., Garvin, D.K., Gorst, C.M., Runquist, J.A., Baur, J.R., Haase, F.C., Ragsdale, S.W. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  19. Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus. Richard, G., De Laurenzi, V., Didona, B., Bale, S.J., Compton, J.G. Nat. Genet. (1995) [Pubmed]
  20. Histone gene clusters of the newt notophthalmus are separated by long tracts of satellite DNA. Stephenson, E.C., Erba, H.P., Gall, J.G. Cell (1981) [Pubmed]
  21. The silent carrier allele: beta thalassemia without a mutation in the beta-globin gene or its immediate flanking regions. Semenza, G.L., Delgrosso, K., Poncz, M., Malladi, P., Schwartz, E., Surrey, S. Cell (1984) [Pubmed]
  22. Long-range chromatin regulatory interactions in vivo. Carter, D., Chakalova, L., Osborne, C.S., Dai, Y.F., Fraser, P. Nat. Genet. (2002) [Pubmed]
  23. Clusters of genes encoding mouse transplantation antigens. Steinmetz, M., Winoto, A., Minard, K., Hood, L. Cell (1982) [Pubmed]
  24. A rhoptry-protein-associated mechanism of clonal phenotypic variation in rodent malaria. Preiser, P.R., Jarra, W., Capiod, T., Snounou, G. Nature (1999) [Pubmed]
  25. Role for a Drosophila Myb-containing protein complex in site-specific DNA replication. Beall, E.L., Manak, J.R., Zhou, S., Bell, M., Lipsick, J.S., Botchan, M.R. Nature (2002) [Pubmed]
  26. Desmosomes and hemidesmosomes. Garrod, D.R. Curr. Opin. Cell Biol. (1993) [Pubmed]
  27. Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Ayton, P.M., Cleary, M.L. Genes Dev. (2003) [Pubmed]
  28. Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription. Ma, T., Van Tine, B.A., Wei, Y., Garrett, M.D., Nelson, D., Adams, P.D., Wang, J., Qin, J., Chow, L.T., Harper, J.W. Genes Dev. (2000) [Pubmed]
  29. Tomato Prf is a member of the leucine-rich repeat class of plant disease resistance genes and lies embedded within the Pto kinase gene cluster. Salmeron, J.M., Oldroyd, G.E., Rommens, C.M., Scofield, S.R., Kim, H.S., Lavelle, D.T., Dahlbeck, D., Staskawicz, B.J. Cell (1996) [Pubmed]
  30. Hematologically and genetically distinct forms of sickle cell anemia in Africa. The Senegal type and the Benin type. Nagel, R.L., Fabry, M.E., Pagnier, J., Zohoun, I., Wajcman, H., Baudin, V., Labie, D. N. Engl. J. Med. (1985) [Pubmed]
  31. Evolution of a D. melanogaster glutamate tRNA gene cluster. Hosbach, H.A., Silberklang, M., McCarthy, B.J. Cell (1980) [Pubmed]
  32. All members of the MHC multigene family respond to thyroid hormone in a highly tissue-specific manner. Izumo, S., Nadal-Ginard, B., Mahdavi, V. Science (1986) [Pubmed]
  33. Pseudomonas syringae phytotoxins: mode of action, regulation, and biosynthesis by peptide and polyketide synthetases. Bender, C.L., Alarcón-Chaidez, F., Gross, D.C. Microbiol. Mol. Biol. Rev. (1999) [Pubmed]
  34. Domain organization of allele-specific replication within the GABRB3 gene cluster requires a biparental 15q11-13 contribution. LaSalle, J.M., Lalande, M. Nat. Genet. (1995) [Pubmed]
  35. Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies. Warner, L.E., Mancias, P., Butler, I.J., McDonald, C.M., Keppen, L., Koob, K.G., Lupski, J.R. Nat. Genet. (1998) [Pubmed]
  36. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Mao, B., Wu, W., Davidson, G., Marhold, J., Li, M., Mechler, B.M., Delius, H., Hoppe, D., Stannek, P., Walter, C., Glinka, A., Niehrs, C. Nature (2002) [Pubmed]
  37. Fragile sites at 16q22 are not at the breakpoint of the chromosomal rearrangement in AMMoL. Simmers, R.N., Sutherland, G.R., West, A., Richards, R.I. Science (1987) [Pubmed]
  38. Recruitment of Thr 319-phosphorylated Ndd1p to the FHA domain of Fkh2p requires Clb kinase activity: a mechanism for CLB cluster gene activation. Reynolds, D., Shi, B.J., McLean, C., Katsis, F., Kemp, B., Dalton, S. Genes Dev. (2003) [Pubmed]
  39. Molecular cloning of the human eosinophil peroxidase. Evidence for the existence of a peroxidase multigene family. Ten, R.M., Pease, L.R., McKean, D.J., Bell, M.P., Gleich, G.J. J. Exp. Med. (1989) [Pubmed]
  40. An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes. Dissen, E., Ryan, J.C., Seaman, W.E., Fossum, S. J. Exp. Med. (1996) [Pubmed]
  41. Hemolytic disease of the newborn caused by a new deletion of the entire beta-globin cluster. Pirastu, M., Kan, Y.W., Lin, C.C., Baine, R.M., Holbrook, C.T. J. Clin. Invest. (1983) [Pubmed]
  42. A human cellular sequence implicated in trk oncogene activation is DNA damage inducible. Ben-Ishai, R., Scharf, R., Sharon, R., Kapten, I. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  43. Two steps in the evolution of Antennapedia-class vertebrate homeobox genes. Kappen, C., Schughart, K., Ruddle, F.H. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
 
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