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MeSH Review

Multigene Family

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Disease relevance of Multigene Family


Psychiatry related information on Multigene Family


High impact information on Multigene Family


Chemical compound and disease context of Multigene Family


Biological context of Multigene Family

  • We analysed a multigenerational family with WSN and found cosegregation of the disease with the keratin gene cluster on chromosome 17 [19].
  • The 9.0 kb histone gene clusters are not adjacent in the genome, but are separated from neighboring clusters by up to 50 kb or more of cluster spacer sequences; some or all of these spacer sequences are members of a predominantly centromeric satellite DNA with a 2235 bp repeating unit [20].
  • Haplotype analysis revealed that the affected son and daughter inherited different epsilon gamma delta beta-globin gene clusters from the father [21].
  • We show that the classical enhancer element, HS2 of the prototypical locus control region (LCR) of the beta-globin gene cluster, is in close physical proximity to an actively transcribed HBB (beta-globin) gene located over 50 kb away in vivo, suggesting a direct regulatory interaction [22].
  • One gene cluster mapped to the L region and a second cluster with seven genes to the Qa-2,3 region of the major histocompatibility complex [23].

Anatomical context of Multigene Family

  • In the rodent malaria agent P. yoelii yoelii, a multigene family codes for merozoite rhoptry proteins of relative molecular mass 235,000 (p235 proteins); these proteins are thought to determine the subset of erythrocytes that the parasites invade [24].
  • Two elements important for amplification of the third chromosome chorion gene cluster, ACE3 and Ori-beta, are directly bound by Orc (origin recognition complex), and two-dimensional gel analysis has revealed that the primary origin used is Ori-beta (refs 7-9) [25].
  • Most of the protein and glycoprotein components are products of members of multigene families, but show specialization for plaque formation and intermediate filament attachment [26].
  • We demonstrate here that primary myeloid progenitors immortalized by various MLL oncoproteins exhibit a characteristic Hoxa gene cluster expression profile, which reflects that preferentially expressed in the myeloid clonogenic progenitor fraction of normal bone marrow [27].
  • Cells in metaphase and telophase have no detectable focus. p220 foci contain cyclin E and are coincident with Cajal bodies (CBs), subnuclear organelles that associate with histone gene clusters on chromosomes 1 and 6 [28].

Associations of Multigene Family with chemical compounds


Gene context of Multigene Family


Analytical, diagnostic and therapeutic context of Multigene Family


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  28. Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription. Ma, T., Van Tine, B.A., Wei, Y., Garrett, M.D., Nelson, D., Adams, P.D., Wang, J., Qin, J., Chow, L.T., Harper, J.W. Genes Dev. (2000) [Pubmed]
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