Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1L9EB8 (3S,4S,10S,13R)-4,10,13- trimethyl-17-[(2R)...

Synonyms: C11522, 24-Methylenelophenol

Bouvier-Navé, P. et al.

Bouvier-Navé, Husselstein, Benveniste,

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High impact information on C11522

In contrast, delipidated microsomes of erg6 Ntsmt2-1 were shown to methylate preferentially 24-methylene lophenol, as expected from an SMT encoded by an smt2 cDNA [1].
According to their deduced amino acid sequences, they were classified in two families, smtl and smt2; in addition, smt2 cDNAs were shown to encode a 24-methylene lophenol C24 methyltransferase [Bouvier-Navé, P., Husselstein, T., Desprez, T. & Benveniste, P. (1997) Eur. J. Biochem. 246, 518-529] [1].

Associations of C11522 with other chemical compounds

In the presence of AdoMet, delipidated microsomes from erg6 Ntsm1-1 efficiently converted cycloartenol into 24-methylene cycloartanol, but did not produce any 24-ethylidene lophenol upon incubation with 24-methylene lophenol [1].

References

Two families of sterol methyltransferases are involved in the first and the second methylation steps of plant sterol biosynthesis. Bouvier-Navé, P., Husselstein, T., Benveniste, P. Eur. J. Biochem. (1998) [Pubmed]

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