Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

SureCN1533890 [(2R,3S,4R,5S)-5-(5,6- dimethylbenzoimidazo...

Synonyms: CHEBI:16837, HMDB03882, AC1L9H5F, C04778, 975-91-7, ...

Cheong, C.G. et al., Schulze, B. et al.

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Disease relevance of alpha-ribazole-5'-P

Nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole (DMB) phosphoribosyltransferase (CobT) from Salmonella enterica plays a central role in the synthesis of alpha-ribazole-5'-phosphate, an intermediate for the lower ligand of cobalamin [1].

High impact information on alpha-ribazole-5'-P

The alpha-nucleotides are then transformed into alpha-ribazole-5'-phosphate and, subsequently, into vitamin B12 [2].

References

Capture of a labile substrate by expulsion of water molecules from the active site of nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) from Salmonella enterica. Cheong, C.G., Escalante-Semerena, J.C., Rayment, I. J. Biol. Chem. (2002) [Pubmed]
Biosynthesis of vitamin B12 in anaerobic bacteria--experiments with Eubacterium limosum on the transformation of 5-hydroxy-6-methyl-benzimidazole, its nucleoside, its cobamide, and of 5-hydroxybenzimidazolylcobamide in vitamin B12. Schulze, B., Vogler, B., Renz, P. Eur. J. Biochem. (1998) [Pubmed]

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