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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Salmonella

  • A newly devised conjugate of the capsular polysaccharide of Salmonella typhi, Vi, bound to nontoxic recombinant Pseudomonas aeruginosa exotoxin A (rEPA), has enhanced immunogenicity in adults and in children 5 to 14 years old and has elicited a booster response in children 2 to 4 years old [1].
  • Chloramphenicol-resistant Salmonella newport traced through hamburger to dairy farms. A major persisting source of human salmonellosis in California [2].
  • Surprisingly, we find that LBP is not required in vivo for the clearance of LPS from the circulation, but is essential for the rapid induction of an inflammatory response by small amounts of LPS or Gram-negative bacteria and for survival of an intraperitoneal Salmonella infection [3].
  • The aspartate receptor of Escherichia coli and Salmonella typhimurium is a cell surface sensory transducer that binds extracellular aspartate and sends a transmembrane signal to the inside of the bacterium [4].
  • Fibronectin binds non-covalently to Gram-positive and Gram-negative bacteria and to yeast but did not appear to be necessary or sufficient for uptake of Staphylococcus aureus and Salmonella typhimurium by several different phagocytic cell types [5].

Psychiatry related information on Salmonella


High impact information on Salmonella

  • We establish that expression of the Mg(2+) transporter MgtA of Salmonella enterica serovar Typhimurium is controlled by its 5' untranslated region (5'UTR) [9].
  • Ceftriaxone-resistant salmonella infection acquired by a child from cattle [10].
  • Iron promoted transcription of PmrA-activated genes and resistance to the antibiotic polymyxin in Salmonella [11].
  • Salmonella cells shifted to higher temperatures, such as those encountered at host entry, showed derepressed tlpA activity. tlpA::lacZ fusions indicated that the promoter itself is insensitive to thermal shifts and that transcription control was exerted by the autorepressor TlpA only [12].
  • Mg2+ as an extracellular signal: environmental regulation of Salmonella virulence [13].

Chemical compound and disease context of Salmonella

  • Chloramphenicol-resistant Salmonella newport traced through hamburger to dairy farms [14].
  • The state of modification of the adenosine residue (A37), found adjacent to the anticodon in tRNAs that recognize codons beginning with U, varies in Salmonella bacteria grown under different physiological conditions [15].
  • Starvation of Salmonella typhimurium for folate in six different ways triggers the intracellular accumulation of a novel ribotide, 5-amino 4-imidazole carboxamide riboside 5'-triphosphate (ZTP) [16].
  • AppppA , ApppGpp , AppppG , ApppG , and ApppA rapidly accumulate to high levels in Salmonella typhimurium following exposure to a variety of oxidizing agents, but not to a variety of other stresses [17].
  • To define more accurately the fluid dynamic properties of the outer membrane as related to function, we have now developed the capability to measure lateral diffusion coefficients in vivo of rhodaminated G30 lipopolysaccharide fused into Salmonella typhimurium G30A filamentous bacteria [18].

Biological context of Salmonella


Anatomical context of Salmonella


Gene context of Salmonella


Analytical, diagnostic and therapeutic context of Salmonella


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  14. Chloramphenicol-resistant Salmonella newport traced through hamburger to dairy farms. Ryan, C.P., Steele, J.H. N. Engl. J. Med. (1987) [Pubmed]
  15. A modified nucleotide in tRNA as a possible regulator of aerobiosis: synthesis of cis-2-methyl-thioribosylzeatin in the tRNA of Salmonella. Buck, M., Ames, B.N. Cell (1984) [Pubmed]
  16. ZTP (5-amino 4-imidazole carboxamide riboside 5'-triphosphate): a proposed alarmone for 10-formyl-tetrahydrofolate deficiency. Bochner, B.R., Ames, B.N. Cell (1982) [Pubmed]
  17. AppppA and related adenylylated nucleotides are synthesized as a consequence of oxidation stress. Bochner, B.R., Lee, P.C., Wilson, S.W., Cutler, C.W., Ames, B.N. Cell (1984) [Pubmed]
  18. Lateral diffusion of lipopolysaccharide in the outer membrane of Salmonella typhimurium. Schindler, M., Osborn, M.J., Koppel, D.E. Nature (1980) [Pubmed]
  19. Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium. Christman, M.F., Morgan, R.W., Jacobson, F.S., Ames, B.N. Cell (1985) [Pubmed]
  20. Salmonella pathogenicity island 2-dependent evasion of the phagocyte NADPH oxidase. Vazquez-Torres, A., Xu, Y., Jones-Carson, J., Holden, D.W., Lucia, S.M., Dinauer, M.C., Mastroeni, P., Fang, F.C. Science (2000) [Pubmed]
  21. Recombinational switch for gene expression. Zieg, J., Silverman, M., Hilmen, M., Simon, M. Science (1977) [Pubmed]
  22. Mutagenic activity of quercetin and related compounds. Bjeldanes, L.F., Chang, G.W. Science (1977) [Pubmed]
  23. Separation of signal transduction and adaptation functions of the aspartate receptor in bacterial sensing. Russo, A.F., Koshland, D.E. Science (1983) [Pubmed]
  24. Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes. Vazquez-Torres, A., Jones-Carson, J., Bäumler, A.J., Falkow, S., Valdivia, R., Brown, W., Le, M., Berggren, R., Parks, W.T., Fang, F.C. Nature (1999) [Pubmed]
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  33. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.P., Ricciardi-Castagnoli, P. Nat. Immunol. (2001) [Pubmed]
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